Fig. 4

Right eye of a patient without morphological improvement after the first follow-up period and ICNV recurrence. At baseline, BCVA was 50 letters and the colour fundus photo (a) showed a pigmentation disorder of the macular centre. SD-OCT (b) showed CNV lesions with subretinal fluid, and the structure of each layer of the retina was unclear. Eleven months later, after the second intravitreal injection, BCVA improved to 69 letters and OCT (c) showed a scar. Fifteen months after initial diagnosis, BCVA decreased to 44 letters, and OCT (d) showed recurring subretinal fluid and a slightly increased thickness of the fovea. One month after an additional intravitreal anti-VEGF therapy (e), subretinal fluid had subsided and scarring remained