Integrated bioinformatics analysis of aberrantly-methylated differentially-expressed genes and pathways in age-related macular degeneration

Table 1 Kyoto encyclopedia of genes and genomes pathway analysis of aberrantly methylated differentially expressed genes in age-related macular degeneration (AMD)

Category	ID	Description	GeneRatio	BgRatio	P value	Q value	geneSymbol	Count
Hypomethylated with high expression
KEGG_PATHWAY	hsa04070	Phosphatidylinositol signaling system	2/13	99/7866	0.01117	0.28231	PIP5K1A/PIP4P2	2
KEGG_PATHWAY	hsa04020	Calcium signaling pathway	2/13	193/7866	0.03911	0.31445	NTSR1/TACR1	2
Hypermethylated with low expression
KEGG_PATHWAY	hsa05031	Amphetamine addiction	3/59	68/7866	0.01423	0.73750	GRIN2C/PPP3CA/STX1A	3
KEGG_PATHWAY	hsa05032	Morphine addiction	3/59	91/7866	0.03057	0.73750	GRK4/PDE10A/PDE4D	3
KEGG_PATHWAY	hsa00600	Sphingolipid metabolism	2/59	47/7866	0.04820	0.73750	PLPP2/SGPL1	2

Table 1. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed for the selected genes. All significantly enriched KEGG pathways with the 24 hypo-methylated, high-expression genes (Hypo-HGs) and 153 hyper-methylated, low-expression genes (Hyper-LGs) are shown. The cut-off criterion was P < 0.05. The results indicated that Hypo-HGs were significantly enriched in the phosphatidylinositol signaling system and calcium signaling pathway, whereas Hyper-LGs were significantly enriched in amphetamine addiction, morphine addiction, and sphingolipid metabolism

ISSN: 1471-2415