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Table 2 Gene Ontology analysis of hypomethylated with high expression genes in age-related macular degeneration (AMD)

From: Integrated bioinformatics analysis of aberrantly-methylated differentially-expressed genes and pathways in age-related macular degeneration

Category

Term

Description

GeneRatio

BgRatio

P value

Q value

GeneSymbol

Count

Hypomethylated with high expression

 GOTERM_BP

GO:0010761

fibroblast migration

2/22

41/18493

0.00108

0.11666

DDR2/PIP5K1A

2

 GOTERM_BP

GO:0031646

positive regulation of neurological system process

2/22

58/18493

0.00214

0.11666

NTSR1/TNR

2

 GOTERM_BP

GO:1901616

organic hydroxy compound catabolic process

2/22

72/18493

0.00328

0.11666

LDHD/NTSR1

2

 GOTERM_BP

GO:0003333

amino acid transmembrane transport

2/22

86/18493

0.00465

0.11666

NTSR1/SLC7A4

2

 GOTERM_BP

GO:0031644

regulation of neurological system process

2/22

127/18493

0.00988

0.11666

NTSR1/TNR

2

 GOTERM_CC

GO:0045121

membrane raft

3/23

304/19659

0.00516

0.13697

NTSR1/SKAP1/TNR

3

 GOTERM_CC

GO:0098857

membrane microdomain

3/23

305/19659

0.00520

0.13697

NTSR1/SKAP1/TNR

3

 GOTERM_CC

GO:0098589

membrane region

3/23

316/19659

0.00574

0.13697

NTSR1/SKAP1/TNR

3

 GOTERM_CC

GO:0032280

symmetric synapse

1/23

11/19659

0.01280

0.16553

NTSR1

1

 GOTERM_CC

GO:0061827

sperm head

1/23

11/19659

0.01280

0.16553

TACR1

1

 GOTERM_MF

GO:0008188

neuropeptide receptor activity

2/20

50/17632

0.00145

0.07933

NTSR1/TACR1

2

 GOTERM_MF

GO:0050662

coenzyme binding

3/20

285/17632

0.00389

0.09513

GCAT/LDHD/UXS1

3

 GOTERM_MF

GO:0034596

phosphatidylinositol phosphate 4-phosphatase activity

1/20

10/17632

0.01129

0.09513

PIP4P2

1

 GOTERM_MF

GO:0008528

G protein-coupled peptide receptor activity

2/20

145/17632

0.01158

0.09513

NTSR1/TACR1

2

 GOTERM_MF

GO:0015174

basic amino acid transmembrane transporter activity

1/20

11/17632

0.01241

0.09513

SLC7A4

1

  1. Table 2. Gene ontology (GO) pathway enrichment analyses were performed for the selected genes. The cut-off criterion was P < 0.05. The top 5 GO terms in each category in which the 24 hypo-methylated, high-expression genes were significantly involved are shown. They were enriched in the biological process of fibroblast migration and positive regulation of neurological system process. The cellular component category revealed enrichment in membrane raft and membrane microdomain. The molecular function category showed enrichment for factors involved in neuropeptide receptor activity and coenzyme binding
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BMC Ophthalmology

ISSN: 1471-2415

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