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Table 2 Aqueous humour cytokine concentrations (pg/mL) in the Coats disease group and the control group

From: Aqueous humour cytokines profiles in eyes with Coats disease and the association with the severity of the disease

Cytokines

Coats disease (n = 36)

stage 2

(n = 15)

stage 3

(n = 21)

Control Group

(n = 15)

P-Value#

P-Value*

LOD

VEGF

77.1 (3.4–379.9)

50.9 (19.7–134.4)

101.2 (3.4–379.9)

23.6 (7.2–72.7)

< 0.001

0.013

4.5

IL-1α

0 (0–1.8)

0 (0–0)

0 (0–1.8)

0 (0–1)

1.0

0.063

1.0

IL-1β

0.8 (0–3.9)

0.7 (0–1.4)

1 (0.3–3.9)

0.7 (0–3.9)

0.329

0.016

2.3

IL-2

4.6 (0–15.5)

2.9 (0.3–8.2)

4.9 (0–15.5)

3.9 (0.6–10.5)

0.756

0.080

11.2

IL-4

1.7 (0.7–2.3)

1.7 (1.2–2.1)

1.6 (0.7–2.3)

1.1 (0.6–1.7)

< 0.001

0.168

1.4

IL-5

1.1 (0–21.3)

0.6 (0–1.3)

2.3 (0–21.3)

0.6 (0–1.3)

0.448

0.001

1.1

IL-6

77.0 (5.3–2566.1)

26.8 (5.3–2566.1)

179.2 (24.9–2096.4)

0.6 (0–199.2)

< 0.001

< 0.001

1.6

IL-8

37.2 (3.7–373.8)

14.7 (3.7–81.5)

71.9 (15.4–373.8)

2 (0.9–31.6)

< 0.001

< 0.001

1.2

IL-10

0.1 (0–3.2)

0 (0–0.4)

0.2 (0–3.2)

0.4 (0–3)

0.035

0.002

0.1

IL-12

0.2 (0–22.7)

0.2 (0–1.8)

0.1 (0–22.7)

0 (0–0.3)

0.016

0.194

0.6

MCP-1

837.1 (298.5–3420)

596.6 (298.5–3420)

1065.2 (505.8–2458.1)

248.4 (135.3–2024.7)

< 0.001

< 0.001

1.3

MIP-1α

2 (0.1–5.9)

1.2 (0.1–3.5)

2.4 (0.7–5.9)

0.2 (0–2)

< 0.001

0.003

0.2

IP-10

421.2 (125.2–1790.2)

257 (125.2–1515.4)

618.8 (143.2–1790.2)

29.5 (3.8–143)

< 0.001

0.010

0.5

VCAM-1

6925.4 (1644.3–39,264.4)

5950.6 (1644.3–19,217.3)

7440.3 (2530.1–39,264.4)

1407.1 (230.9–12,390.3)

0.001

0.205

12.2

ICAM-1

1816.2 (559.5–14,769.5)

1557 (559.5–9125)

1903.6 (654.1–14,769.5)

100.9 (2.7–1938.8)

< 0.001

0.221

25.7

bFGF

10.5 (1–117.4)

8.6 (1–117.4)

11.7 (1.9–28.8)

13.5 (3.3–29.4)

0.162

0.130

3.4

TNF-α

3.7 (0–74.4)

2.8 (0–74.4)

4 (0–9.7)

3.2 (0.4–6.4)

0.882

0.189

1.2

IFN-γ

2.9 (0.2–9.4)

2.4 (0.2–3.6)

3.3 (1.4–9.4)

2.8 (0.1–5.9)

0.539

0.011

0.8

Fractalkine

3.8 (0–23.9)

6.3 (1.5–23.9)

2.7 (0–10.8)

4.2 (0–23.9)

0.680

0.003

22.3

RANTES

0.5 (0.1–20.4)

0.5 (0.4–2.3)

0.6 (0.1–20.4)

0.4 (0–64.2)

0.003

0.046

0.0

G-CSF

1.8 (1–4.7)

1.7 (1–2.7)

1.9 (1.1–4.7)

1.1 (0.6–1.4)

< 0.001

0.040

1.6

GM-CSF

0.9 (0–3.8)

0.9 (0–1.8)

0.9 (0.4–3.8)

1.0 (0–3.9)

0.687

0.254

0.2

  1. Values in bold font are statistically significant at P < 0.05
  2. LOD limit of detection, VEGF vascular endothelial growth factor, IL interleukin, MCP-1 monocyte chemoattractant protein-1, MIP-1α macrophage inflammatory protein-1α, IP-10 interferon-γ-inducible protein-10, VCAM vascular cell adhesion molecule, ICAM intercellular cell adhesion molecule, bFGF basic fibroblast growth factor, TNF-α tumor necrosis factor-α, IFN-γ interferon-γ, RANTES regulated upon the activation of normal T cell expressed and secreted, G-CSF granulocyte colony-stimulating factor, GM-CSF granulocyte macrophage colony-stimulating factor
  3. #Wilcoxon Mann–Whitney test was used for comparisons between the Coats disease group and the control group
  4. *Wilcoxon Mann–Whitney test was used for comparisons between stage 2 and stage 3
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BMC Ophthalmology

ISSN: 1471-2415

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