Safety and efficacy of ripasudil in Japanese patients with glaucoma or ocular hypertension: 12-month interim analysis of ROCK-J, a post-marketing surveillance study

Table 2 Adverse drug reactions

Adverse drug reactions, n (%)	N = 3359
No. of patients with ADR	626 (18.6)
Eye disorders
Conjunctival hyperemia^a	223 (6.6)
Blepharitis^b	189 (5.6)
Conjunctivitis^c	141 (4.2)
Eye pruritus	44 (1.3)
Punctate keratitis	25 (0.7)
Eye pain	16 (0.5)
Vision blurred	12 (0.4)
Corneal erosion	9 (0.3)
Eye irritation	9 (0.3)
Eyelid edema	9 (0.3)
Dry eye	8 (0.2)
Erythema of eyelid	4 (0.1)
Eye discharge	4 (0.1)
Corneal disorder	4 (0.1)
Conjunctival follicles	3 (0.1)
Lacrimation increased	3 (0.1)
Eyelids pruritus	3 (0.1)
Keratitis^d	3 (0.1)
Abnormal sensation in eye	2 (0.1)
Eyelid ptosis	2 (0.1)
Foreign body sensation in eyes	2 (0.1)
Cataract^e	2 (0.1)
Other^f (incidence of each)	1 (< 0.1)
Other ADRs
Dermatitis contact	6 (0.2)
Headache	5 (0.2)
Dermatitis allergic	3 (0.1)
Dizziness	3 (0.1)
Intraocular pressure increased	3 (0.1)
Somnolence	2 (0.1)
Nausea	2 (0.1)
Other^g (incidence of each)	1 (< 0.1)

ADR adverse drug reaction
^a Including ocular hyperemia
^b Including blepharitis allergic
^c Including conjunctivitis allergic
^d Including allergic keratitis
^e Including nuclear cataract
^f One patient each developed asthenopia, conjunctival erosion, conjunctival hemorrhage, conjunctival edema, corneal epithelium defect, corneal edema, eczema of the eyelids, macular edema, meibomianitis, scintillating scotoma, eyelid skin dryness, administration site dermatitis, hordeolum
^g One patient each developed erythema, pruritus, urticaria, cerebral infarction, cough, dyspnea, epistaxis, malaise, dermatitis, bradycardia, palpitations, rhinitis, otitis externa, dysgeusia

ISSN: 1471-2415