Table 2 Unadjusted and adjusted HR for treatment modification
Variable | Unadjusted HR (95% CI) | P value | Adjusted HR (95% CI) | P value |
|---|---|---|---|---|
Combination drug | ||||
With fixed combination drug | 1.065 (0.913, 1.243) | 0.4205 | 0.988 (0.811, 1.203) | 0.9016 |
Without fixed combination drug | Referent | Referent | ||
Age (years) | 1.000 (0.994, 1.007) | 0.9078 | 0.993 (0.984, 1.003) | 0.1634 |
Gender | ||||
Male | Referent | Referent | ||
Female | 1.025 (0.893, 1.177) | 0.722 | 1.048 (0.863, 1.273) | 0.6338 |
Smoking status | ||||
Non-smoker | Referent | Referent | ||
Current smoker | 1.221 (0.996, 1.496) | 0.0546 | 1.216 (0.982, 1.506) | 0.0729 |
Type of glaucoma (ICD-10 code) | ||||
Glaucoma suspect (H40.0) | Referent | Referent | ||
Primary open angle glaucoma (H40.1) | 0.800 (0.649, 0.986) | 0.0361 | 0.834 (0.643, 1.082) | 0.1719 |
Secondary glaucoma (H40.3 to H40.6) | 1.678 (1.231, 2.288) | 0.0011 | 1.512 (1.003, 2.280) | 0.0484 |
Unspecified glaucoma (H40.9) | 1.006 (0.853, 1.187) | 0.9403 | 1.070 (0.868, 1.319) | 0.5243 |
Hospital size | ||||
≤ 19 hospital beds | Referent | Referent | ||
20–499 hospital beds | 0.912 (0.734, 1.135) | 0.4098 | 0.879 (0.667, 1.158) | 0.3582 |
≥ 500 hospital beds | 0.852 (0.717, 1.013) | 0.0702 | 0.859 (0.687, 1.074) | 0.1832 |
Systolic blood pressure (mmHg) | 1.005 (1, 1.009) | 0.0618 | 1.002 (0.994, 1.011) | 0.5637 |
Diastolic blood pressure (mmHg) | 1.007 (1, 1.014) | 0.0595 | 1.005 (0.993, 1.017) | 0.4169 |
Duration of first-line treatment (months) | 0.987 (0.982, 0.993) | < 0.0001 | 0.988 (0.981, 0.994) | 0.0002 |