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Table 3 Interaction of CFB (rs4151667) polymorphism genotypes with C3 (rs2230199)/CFH (Y402H) polymorphisms genotypes in AMD and control groups

From: Role of complement factor B rs4151667 (L9H) polymorphisms and its interactional role with CFH Y402H and C3 rs2230199 (R102G) risk variants in age-related macular degeneration: a case control study

 

CFB

Case

Control

OR

95% CI

P

Lower

Upper

C3

Non-CC

Non-TT

4

7

0.45

0.13

1.54

0.202

TT

95

52

1.76

1.17

2.66

0.007

CC

Non-TT

10

17

0.44

0.20

1.00

0.049

TT

126

111

0.79

0.54

1.17

0.238

CFH

Non-TT

Non-TT

15

12

0.73

0.33

1.62

0.438

TT

167

64

3.76

2.32

6.11

0.000

TT

Non-TTa

0

4

0.00

0.00

0.897

0.019

TT

28

46

0.27

0.16

0.46

0.000

  1. a CI and P-value is calculated based on exact method and OR based on logistic regression. Discrepancy regarding the sample size in each combination is caused by missing data. C3 non-CC: risk genotypes of C3 rs2230199 (R102G), CFH Non-TT: risk genotypes of CFH Y402H
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BMC Ophthalmology

ISSN: 1471-2415

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