Fig. 1

Measurement points of optical coherence tomography angiography (OCTA) scans. a-d OCTA scans of control subjects. a Peripapillary retinal microvasculature centers on the nerve head. The ring-shape region of interest is divided into six parts automatically as nasal (N), inferior nasal (IN), inferior temporal (IT), temporal (T), superior temporal (ST), and superior nasal (SN). Signals inside the inner circle are defined as vessel density of the inside disc. Pixels of large blood vessels will be excluded during analysis. b The boundaries used for segmentation are indicated by the green line (inner plexiform layer, IPL) and the red line (inner limiting membrane, ILM). The radial parapapillary capillaries (RPC) from ILM to the retinal nerve fiber layer (RNFL) is analyzed in the scans of the nerve head. The arrow represents the nasal direction. c Perifoveal retinal microvasculature centers on the macula showing the superficial retinal vascular plexus (SVP). The area inside the inner circle, including the foveal avascular zone (FAZ), is excluded from the analysis. The ring-shaped region of interest is automatically separated as hemi-superior (Hemi-S), hemi-inferior (Hemi-I), nasal (N), inferior (I), tempo (T), and superior (S). d SVP from ILM to IPL is analyzed. The red line and the green line possessed the same definition as the lines in image (b). e-h Images of juvenile ocular hypertension (JOHT) subjects