Table 1 EBAMD Subject characteristics: FMPD (Foveal Macular Pigment Dip) versus No Dip (corrected for age). Mean ± SD data is presented unless otherwise stated. Statistical significance is presented in bold

Offspring subjects (%)

130 (100%)

53 (41%)

77 (59%)

Age (years)

62.8 ± 8.6

60.6 ± 8.0

64.4 ± 8.7

0.012

Gender

36 (28%):

11 (21%):

25 (32%):

0.14

Male: Female (%)

94 (72%)

42 (79%)

52 (68%)

% Body Fat (bioelectric impedance)

32.6 ± 7.8

32.6 ± 7.7

32.5 ± 8.0

0.92

Body Mass Index (kg/m²)

25.4 ± 4.8

25.4 ± 5.3

25.5 ± 4.5

0.49

ARIS MP Peak (du)

0.80 ± 0.21

0.85 ± 0.20

0.77 ± 0.21

0.39

ARIS MP Volume

3963 ± 1222

4310 ± 1156

3723 ± 1217

0.10

Central retinal thickness (μm) (n = 72)

238 ± 21.0

232 ± 17.8

243 ± 22.2

0.010

Visual acuity (converted to decimals)

0.92 ± 0.22

0.91 ± 0.22

0.93 ± 0.21

0.61

Contrast sensitivity (AUC)

362 ± 109

362 ± 104

361 ± 114

0.94

DHA (%)

4.94 ± 1.42

4.62 ± 1.36

5.15 ± 1.42

0.040

EPA (%)

1.07 ± 0.68

0.92 ± 0.559

1.16 ± 0.744

0.10

HS-n3 index (%)

6.03 ± 1.99

5.55 ± 1.80

6.34 ± 2.05

0.029

Serum L (μg/dL)

24.8 ± 15.7

23.7 ± 13.1

25.6 ± 17.3

0.98

Serum Z (μg/dL)

6.89 ± 6.12

6.34 ± 5.41

7.28 ± 6.59

0.34

L: Z ratio

4.45 ± 1.84

4.75 ± 2.20

4.24 ± 1.52

0.31

Skin carotenoids

34,525 ± 13,970

33,528 ± 14,331

35,225 ± 13,766

0.50

 C677T

57 (46%): 47 (38%): 20 (16%)

26 (52%): 18 (36%): 6 (12%)

31 (42%): 29 (39%): 14 (19%)

0.44

 AI298C

45 (36%): 57 (46%): 22 (18%)

16 (32%): 23 (46%): 11 (22%)

29 (39%): 34 (46%): 11 (15%)

0.53