Table 3 Mean Change in ETDRS in BCVA, Retinal Thickness During the Study

Age (years)

18–64

54.6 (20.83)

n = 53

67.9 (20.19)

n = 36

10.6 (18.47)

n = 36

0.0016

464.5 (218.03)

n = 53

264.8 (127.57)

n = 33

161.9 (267.60)

n = 33

0.0015

65–74

52.7 (21.55)

n = 37

62.0 (19.86)

n = 22

7.7 (13.70)

n = 22

0.0156

501.2 (203.25)

n = 36

317.4 (240.69)

n = 17

154.6 (259.77)

n = 16

0.0310

75–84

47.1 (28.19)

n = 9

37.5 (42.30)

n = 6

−9.5 (27.06)

n = 6

0.4291

493.9 (280.42)

n = 9

307.2 (161.36)

n = 5

273.0 (214.59)

n = 5

0.0466

> = 85

11.0

n = 1

20.0

n = 1

9.0

n = 1

–

408.0

n = 1

–

–

–

Gender

Male

48.9 (23.83)

n = 57

58.8 (27.42)

n = 36

6.8 (17.45)

n = 36

0.0246

487.3 (218.94)

n = 56

254.6 (119.33)

n = 33

198.7 (225.43)

n = 32

< 0.0001

Female

58.1 (18.24)

n = 43

66.7 (19.61)

n = 29

8.8 (19.72)

n = 29

0.0232

470.4 (214.88)

n = 43

330.4 (224.02)

n = 22

− 128.3 (301.35)

n = 22

0.0589

Smoking Status

Smoker

48.8 (29.20)

n = 10

77.8 (5.08)

n = 6

13.7 (9.07)

n = 6

0.0141

494.2 (266.86)

n = 10

242.5 (77.94)

n = 6

− 254.5 (401.63)

n = 6

0.1813

Non-smoker

53.3 (21.20)

n = 90

60.7 (25.04)

n = 59

7.1 (19.01)

n = 59

0.0057

478.3 (211.58)

n = 89

290.1 (179.29)

n = 49

− 159.5 (239.33)

n = 48

<.0001

Previous treatment for RVO

Not treated

53.4 (20.07)

n = 79

62.8 (24.06)

n = 50

8.4 (20.39)

n = 50

0.0052

501.9 (225.96)

n = 79

288.9 (191.19)

n = 43

−187.9 (280.10)

n = 43

<.0001

Laser treatment

54.0 (24.23)

n = 4

51.5 (32.23)

n = 4

2.5 (8.66)

n = 4

0.6042

454.8 (148.30)

n = 4

306.7 (62.01)

n = 3

122.7 (228.71)

n = 3

0.4510

Previous anti-VEGF therapy

50.8 (28.58)

n = 21

60.6 (26.27)

n = 15

5.3 (9.01)

n = 15

0.04

393.3 (147.28)

n = 20

270.8 (65.49)

n = 12

100.0 (135.69)

n = 11

0.0346