Table 1 Characteristics of the case series: Predisposing factors and presenting symptoms
From: Brimonidine-associated uveitis – a descriptive case series
ID | Age, Gender | Eyes affected | Uveitis signs (conjunctival hyperemia present in all affected eyes) | Glaucoma therapy | Brimonidine Use | Type of glaucoma | Prior surgery | Auto- immune or rheumatoid disease | Iris pigmentation | logMAR visual acuity R/ L |
|---|---|---|---|---|---|---|---|---|---|---|
1 | 80’s-90’s, f | Both | KP, cells 1+ (R + L), Synechia (R) | Both: Br | 13 mo. | NTG | No | No ** | Dark | 0.6 0.4 |
2 | 60’s-70’s, m | Both | KP, cells 1+ (R + L), synechia (R) | Both: Br, DoTim, Tra | > 4 mo. | OHT | TE, N, 4x CPC, Psph (14 mo.) (R); 4x CPC (L) | Crohn’s disease * | Dark | 0.0 0.0 |
3 | 80’s-90’s, f | Both | unpigm. KP and cells 1+ (R + L), synechia in the chamber angle (L) | Both: Br, BzTim | n.a. | NTG | Psph (8 mo.) (R); Psph (7 mo.) (L) | No * | – | 0.5 0.1 |
4 | 70’s-80’s, f | Both | KP, flare 2+ (R + L) | Both: Br, Do, BimTim, Pil, Acet | n.a. | POAG | Psph (3 years) (R); Psph (3 years) (L) | No | Dark | 0.6 0.5 |
5 | 60’s-70’s, m | Left | KP (L), flare 2+ (R + L) | Both: Br, BimTim | > 24 mo. | POAG | LTP(R); LTP(L) | Hay fever | Pale | 0.0 0.1 |
6 | 70’s-80’s, f | Both | KP (L) | Both: Br, DoTim, Taf, Pil, pred | n.a. | PXG | Psph (n.a.), XEN, 2x N (R); Psph (n.a.), 2x XEN, PPV, cyclocryocoagulation (L) | Intermediate uveitis 2 years earlier | Pale | 0.22 0.7 |
7 | 80’s-90’s, f | Left | KP (L) | Both: Lat; Left: BzBrim | 2 mo. | POAG | Psph (n.a.), cyclocryocoagulation (R); Psph (n.a.) (L) | No | Pale | 0.5 0.6 |
8 | 80’s-90’s, m | Both | KP (R > L) | Both Br, DoTim | 6 mo. | PXG (R); PXG - > sec. Glaucoma ^^ (L) | Psph (4 mo.) (R) | No | Pale | 0.22 3 |
9 | 80’s-90’s, m | Left | KP (L) | Both: Do, Taf; Left: Br | 31 mo. | PXG | Psph (3 years), TE, multiple AntiVEGF-IVOMs (R); TE, TE-Revision, Psph (3 years) (L) | No | Pale | 0.22 0.22 |
10 | 70’s-80‘s, m | Right | KP, DF, cells 2+, flare 2+ (R) | Both: Br, DoTim | 18 mo. | POAG - > sec. Glaucoma ^ (R); POAG (L) | Psph (1 year) (R); Psph (1 year) (L) | No ** | Pale | 0.6 0.4 |
11 | 40’s-50’s, m | Left | – | Both: Br, BzTim | > 49 mo. | sec. Glaucoma | AC-IOL (R); AC-IOL, 2x PPV, AC-IOL-Expl. + Psph (4 years), 2x steroidal IVOMs, CPC (L) | No * | – | 0.4 1.0 |
12 | 70’s-80’s, f | Right | whitish KP (R), vascularized cornea (L) | Both: BzBrim, BimTim | 24 mo. | POAG | Psph (n.a.) (R); Aphak (n.a.) (L) | No | Pale | 0.3 3 |
13 | 70’s-80’s, f | Both | large whitish KP (R + L) | Both: BzBrim, Lat | n.a. | PXG | No (R); Psph+iStent+TA (9 mo.) (L) | n.a. | – | 0.4 1.8 |
14 | 70’s-80’s, f | Both | KP (R < L), cells 1+, flare 2+ | Both: Br, LatTim | 0.25 mo. | PXG | Psph (n.a.) (R); Psph (n.a.), TE (L) | Hay fever, allergic asthma ** | Dark | 0.6 3 |
15 | 80’s-90’s, f | Both | KP (R + L), cells 2+, flare 2+ | Both: Br, DoTim, Lat, BzTim | n.a. | PXG | Psph (1 year) (R); Psph (1 mo.), TE, N (L) | No | Dark | 0.3 0.22 |
16 | 80’s-90’s, m | Both | KP (R + L) | Both: Br, BzTim | n.a. | PXG | Psph (1.5 years) (R); Psph (4 years) (L) | No | – | 2.3 2.3 |