Fig. 6
From: Ferulic acid attenuates microglia-mediated neuroinflammation in retinal degeneration
FA modulated STAT1 phosphorylation and IRF8 activation in vivo and vitro. The retina of FA-treated rd10 mice exhibited lower STAT1 signalling and IRF8 expression than PBS-treated retinae, as evaluated by western blotting. In vitro, LPS upregulated the expression of IRF8 and STAT1 phosphorylation in BV2 cells, while FA treatment reduced both STAT1 activation and IRF8 expression levels in these cells