Fig. 2
a Enlargement of GA before and after the diagnosis of a complicating CNV. The mean GA of 2.11 ± 1.48 (range: 0.79–4.35) mm2 at baseline increased to a mean 4.55 ± 2.98 (2.31–10.51) mm2 at CNV diagnosis after a mean 1.42 ± 0.48 (0.77–1.80) years (p = 0.03). In the following 5.06 ± 3.01 (1.15–7.88) years until end of follow-up, GA increased to a mean 8.58 ± 3.50 (range: 4.37–14.07) mm2 (p = 0.004), resulting in a total mean growth rate of 1.46 ± 0.82 (0.77–3.03) mm2/year (p = 0.004). b Rate of enlargement of GA before and after the diagnosis of a complicating CNV. There was no significant difference between the mean enlargement rate pre-CNV (1.58 ± 0.99) and post-CNV diagnosis with resulting anti-VEGF treatment (1.39 ± 0.65 mm2/year; p = 0.44). An intra-individual comparison of the total enlargement rate during the complete follow-up between study and partner eyes showed no significant difference (1.63 ± 0.99 vs. 1.76 ± 1.11 mm2/year; p = 0.86)