Fig. 3
From: IgG4-related disease presenting as recurrent scleritis combined with optic neuropathy
Microscopic examination of the pulmonary nodule revealed necrotizing inflammation, dense fibrosis, marked lymphoplasmacytic infiltration, and increased IgG4+ plasma cells (a, × 200, Hematoxylin and eosin staining). Immunohistochemical staining showed an increased number of IgG4+ plasma cells (b, more than 50 IgG4 cells per HPF, × 400) and an elevated IgG4+/IgG+ ratio (c and d, a ratio of IgG4+ to IgG+ cells of 46.5%)