Table 1 Baseline characteristics by study group of patients with subfoveal CNV due to age-related macular degeneration

Female (%)

51 (50)

79 (57)

77 (59)

54 (52)

0.5

Mean age ± SD

77.7 ± 7.8

76.9 ± 7.5

78.6 ± 6.9

80.8 ± 6.3

< 0.0001

Angiographic lesion subtype^a

< 0.0001

 Predominantly classic (%)

40 (39)

82 (59)

33 (25)

49 (48)

 Minimally classic (%)

11 (11)

16 (12)

24 (19)

10 (10)

 Occult with no classic (%)

46 (45)

36 (26)

59 (45)

36 (35)

 Cannot classify: obscuring lesion (%)

5 (5)

4 (3)

14 (11)

6 (6)

 Cannot classify: photo quality (%)

–

–

–

2 (2)

Angiographic non-CNV components of lesion^a

 Elevated blocked hypofluorescence

1 (1)

2 (1)

1 (1)

–

0.7

 Blood

36 (35)

74 (54)

58 (45)

54 (52)

0.02

 PED

6 (6)

8 (6)

15 (12)

6 (6)

0.2

 Fibrous tissue

–

–

1 (1)

–

0.5

Angiographic measurements

 Size CNV (disc diameters) ± SD

1.3 ± 0.8

1.4 ± 0.8

1.2 ± 0.8

1.2 ± 0.7

0.3

 Missing size CNV

2

1

–

–

 Size of lesion (disc diameters) ± SD

1.8 ± 0.8

1.8 ± 0.8

2.0 ± 0.8

1.9 ± 0.8

0.3

Angiographic classification of fellow eye^b

< 0.0001

 No nAMD (%)

11 (11)

22 (16)

26 (20)

23 (22)

 Early or intermediate nAMD (%)

40 (39)

41 (30)

51 (39)

30 (29)

 Advanced nAMD (%)

49 (48)

64 (46)

51 (39)

35 (34)

 Cannot classify: photo quality (%)

2 (2)

11 (8)

2 (2)

15 (15)

Visual acuity

 Study eye LogMAR ± SD

0.82 ± 0.49

0.73 ± 0.37

0.73 ± 0.41

0.77 ± 0.48

0.3

 Fellow eye LogMAR ± SD

0.67 ± 0.73

0.64 ± 0.75

0.70 ± 0.82

0.64 ± 0.76

0.9

 Best eye LogMAR ± SD

0.38 ± 0.33

0.36 ± 0.35

0.35 ± 0.32

0.38 ± 0.40

0.9