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Table 2 Validating set: areas under the ROC curves of various optical coherence tomography parameters

From: Diagnostic capability of a linear discriminant function applied to a novel Spectralis OCT glaucoma-detection protocol

 

AUC

95% CI

AUC P*

Cut-off Point

Sens (%)

Spec (%)

+LR

-LR

LDF

0.875

0.755–0.950

<  0.001

>  0.309

70.37

96.15

18.30

0.31

pRNFL glaucoma global

0.879

0.778–0.946

<  0.001

≤ 92

91.18

73.53

3.44

0.12

BMO–MRW global

0.846

0.736–0.923

<  0.001

≤ 250.08

75.76

96.97

25

0.25

pRNFL 3.5 global

0.844

0.724–0.927

<  0.001

≤ 86

75.86

89.29

7.08

0.27

pRNFL 4.1 global

0.812

0.684–0.905

<  0.001

≤ 70

67.86

92.59

9.16

0.35

pRNFL 4.7 global

0.816

0.689–0.908

<  0.001

≤ 64

71.43

88.89

6.43

0.32

  1. MedCalc software was used to calculate the cut-off points (points with the best sensitivity-specificity balance)
  2. P*: level of statistical significance (< 0.05). Bold text indicates statistically significant results (p < 0.05)
  3. AUC Area under the ROC curve, CI Confidence interval, +LR Positive likelihood ratio, −LR Negative likelihood ratio, BMO–MRW Bruch membrane opening–minimum rim width, LDF Linear discriminant function, pRNFL peripapillary retinal nerve fibre layer