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Table 2 Comparison of patients in the treatment-naïve and pre-treated groups who were treated with a fixed-dosing intravitreal aflibercept regimen

From: One-year outcomes of fixed-dosing Aflibercept therapy for pre treated and naive polypoidal choroidal vasculopathy patient

 

Treatment-naïve case (n=12)

Pre-treated (n=13)

P-value

(Treatment-naïve vs. Pre-treated)

Baseline

12 months

Δ and P-value

Baseline

12 months

Δ and P-value

BCVA at 12 months from baseline

(ETDRS letters)

66.58±14.79

76.36±6.59

Δ =9.78 letters

p= 0.005a

64.46±16.52

64.46±14.61

Δ = 0 letters

p= 1.000a

0.004b

Retinal thickness at 12 months from baseline (um)

462±160

243.55±162

Δ = 218.45

p= 0.000a

356.08±145

303.69±139

Δ = 52.39

p= 0.23a

0.009b

Number and Proportion of patients with complete polyp regression at month 12 n (%)

 

5 (41.6%)

  

5 (38.4%)

 

0.87c

Number and Proportion of patients with dry retina at month 12 n (%)

 

8 (67%)

  

7 (53.8%)

 

0.51c

  1. a Paired T-test b T-test c Chi-squared test)