Association of UCP1 and UCP2 variants with diabetic retinopathy susceptibility in type-2 diabetes mellitus patients: a meta-analysis

Table 2 Extracted genotype data from the included studies

Variant	Controls (n)	Cases (n)	Study	Cases					Controls					P_HWE	MAF
UCP1 rs1800592				GG	GA	AA	G	A	GG	GA	AA	G	A
	DWR (2260)	DR (1386)	Jin 2017	140	251	139	531	529	338	669	338	1345	1345	0.85	50%
			Rudofsky 2007	5	63	60	73	183	18	173	198	209	569	0.01	27%
			Zhang 2014	122	217	105	461	427	79	161	94	319	349	0.53	50%
			Zietz 2006	8	72	114	88	300	15	117	183	147	483	0.50	23%
	DWR (649)	NPDR (366)	Zhang 2014	57	110	60	224	230	79	161	94	319	349	0.53	48%
			Zietz 2006	6	49	84	61	217	15	117	183	147	483	0.50	23%
	DWR (649)	PDR (272)	Zhang 2014	65	107	45	237	197	79	161	94	319	349	0.53	50%
			Zietz 2006	2	23	30	27	83	15	117	183	147	483	0.50	24%
UCP2 rs659366				AA	AG	GG	A	G	AA	AG	GG	A	G
	DWR (2244)	DR (1236)	Jin 2017	68	261	201	397	663	177	654	513	1008	1680	0.16	37%
			Rudofsky 2007	17	62	49	96	160	49	186	154	284	494	0.54	37%
			Shen 2014	59	144	102	262	348	38	73	38	149	149	0.81	45%
			Zhou 2018	57	122	30	236	182	33	110	56	176	222	0.09	50%
	DWR (348)	NPDR (194)	Shen 2014	23	54	25	100	104	38	73	38	149	149	0.81	50%
			Zhou 2018	25	61	6	111	73	33	110	56	176	222	0.09	49%
	DWR (606)	PDR (560)	Crispim 2010	45	131	64	221	259	30	116	112	176	340	1.00	40%
			Shen 2014	36	90	77	162	244	38	73	38	149	149	0.81	44%
			Zhou 2018	32	61	24	125	109	33	110	56	176	222	0.09	48%

DWR diabetes without retinopathy, DR diabetic retinopathy, PDR proliferative diabetic retinopathy, NPDR non-proliferative diabetic retinopathy, HWE Hardy-Weinberg equilibrium, MAF minor allele frequency, n: number

ISSN: 1471-2415