|
Comparison
|
Variant
|
Model
|
Effect
|
Pooled OR (95% C.I.)
|
Z
|
Pz
|
I2
|
P for heterogeneity
|
|---|
|
DR vs DWR
|
UCP1 rs1800592
|
Allelic (G vs A)
|
Fixed
|
1.03 (0.93, 1.13)
|
0.51
|
0.609
|
0.0%
|
0.533
|
|
Homozygous (GG vs AA)
|
Fixed
|
1.10 (0.88, 1.37)
|
0.85
|
0.398
|
0.0%
|
0.375
|
|
Heterozygous (AG vs AA)
|
Fixed
|
1.00 (0.84, 1.19)
|
0.01
|
0.992
|
0.0%
|
0.431
|
|
Dominant (GG + AG vs AA)
|
Fixed
|
1.03 (0.87, 1.21)
|
0.31
|
0.760
|
8.6%
|
0.335
|
|
Recessive (GG vs AG + AA)
|
Fixed
|
1.11 (0.92, 1.33)
|
1.07
|
0.284
|
0.0%
|
0.684
|
|
DR vs DWR
|
UCP2 rs659366
|
Allelic (A vs G)
|
Random
|
1.00 (0.79, 1.27)
|
0.02
|
0.983
|
79.3%
|
0.001
|
|
Homozygous (AA vs GG)
|
Random
|
1.17 (0.63, 2.17)
|
0.49
|
0.623
|
82.7%
|
0.001
|
|
Heterozygous (GA vs GG)
|
Random
|
1.10 (0.79, 1.55)
|
0.56
|
0.572
|
66.8%
|
0.029
|
|
Dominant (AA+GA vs GG)
|
Random
|
1.12 (0.75, 1.67)
|
0.55
|
0.584
|
78.4%
|
0.003
|
|
Recessive (AA vs GA + GG)
|
Random
|
1.07 (0.73, 1.57)
|
0.35
|
0.73
|
66.1%
|
0.031
|
- DM diabetes mellitus, DWR diabetes without retinopathy, DR diabetic retinopathy, PDR proliferative diabetic retinopathy, NPDR non-proliferative diabetic retinopathy, C.I. confident interval
