Table 3 Pooled effect on the association of UCPs variants with DR in type-2 DM patients
Comparison | Variant | Model | Effect | Pooled OR (95% C.I.) | Z | Pz | I2 | P for heterogeneity |
|---|---|---|---|---|---|---|---|---|
DR vs DWR | UCP1 rs1800592 | Allelic (G vs A) | Fixed | 1.03 (0.93, 1.13) | 0.51 | 0.609 | 0.0% | 0.533 |
Homozygous (GG vs AA) | Fixed | 1.10 (0.88, 1.37) | 0.85 | 0.398 | 0.0% | 0.375 | ||
Heterozygous (AG vs AA) | Fixed | 1.00 (0.84, 1.19) | 0.01 | 0.992 | 0.0% | 0.431 | ||
Dominant (GG + AG vs AA) | Fixed | 1.03 (0.87, 1.21) | 0.31 | 0.760 | 8.6% | 0.335 | ||
Recessive (GG vs AG + AA) | Fixed | 1.11 (0.92, 1.33) | 1.07 | 0.284 | 0.0% | 0.684 | ||
DR vs DWR | UCP2 rs659366 | Allelic (A vs G) | Random | 1.00 (0.79, 1.27) | 0.02 | 0.983 | 79.3% | 0.001 |
Homozygous (AA vs GG) | Random | 1.17 (0.63, 2.17) | 0.49 | 0.623 | 82.7% | 0.001 | ||
Heterozygous (GA vs GG) | Random | 1.10 (0.79, 1.55) | 0.56 | 0.572 | 66.8% | 0.029 | ||
Dominant (AA+GA vs GG) | Random | 1.12 (0.75, 1.67) | 0.55 | 0.584 | 78.4% | 0.003 | ||
Recessive (AA vs GA + GG) | Random | 1.07 (0.73, 1.57) | 0.35 | 0.73 | 66.1% | 0.031 |