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Table 3 Pooled effect on the association of UCPs variants with DR in type-2 DM patients

From: Association of UCP1 and UCP2 variants with diabetic retinopathy susceptibility in type-2 diabetes mellitus patients: a meta-analysis

Comparison Variant Model Effect Pooled OR (95% C.I.) Z Pz I2 P for heterogeneity
DR vs DWR UCP1 rs1800592 Allelic (G vs A) Fixed 1.03 (0.93, 1.13) 0.51 0.609 0.0% 0.533
Homozygous (GG vs AA) Fixed 1.10 (0.88, 1.37) 0.85 0.398 0.0% 0.375
Heterozygous (AG vs AA) Fixed 1.00 (0.84, 1.19) 0.01 0.992 0.0% 0.431
Dominant (GG + AG vs AA) Fixed 1.03 (0.87, 1.21) 0.31 0.760 8.6% 0.335
Recessive (GG vs AG + AA) Fixed 1.11 (0.92, 1.33) 1.07 0.284 0.0% 0.684
DR vs DWR UCP2 rs659366 Allelic (A vs G) Random 1.00 (0.79, 1.27) 0.02 0.983 79.3% 0.001
Homozygous (AA vs GG) Random 1.17 (0.63, 2.17) 0.49 0.623 82.7% 0.001
Heterozygous (GA vs GG) Random 1.10 (0.79, 1.55) 0.56 0.572 66.8% 0.029
Dominant (AA+GA vs GG) Random 1.12 (0.75, 1.67) 0.55 0.584 78.4% 0.003
Recessive (AA vs GA + GG) Random 1.07 (0.73, 1.57) 0.35 0.73 66.1% 0.031
  1. DM diabetes mellitus, DWR diabetes without retinopathy, DR diabetic retinopathy, PDR proliferative diabetic retinopathy, NPDR non-proliferative diabetic retinopathy, C.I. confident interval
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