Skip to main content

Table 4 Subgroup analysis on subtype of DR and ethnicity

From: Association of UCP1 and UCP2 variants with diabetic retinopathy susceptibility in type-2 diabetes mellitus patients: a meta-analysis

Variant Cases vs Controls Ethnicity Allelic Homozygous Heterozygous Dominant Recessive
OR (95% C.I.) OR (95% C.I.) OR (95% C.I.) OR (95% C.I.) OR (95% C.I.)
UCP1 rs1800592    G vs A GG vs AA AG vs AA GG + AG vs AA GG vs AG + AA
NPDR vs DWR   1.02 (0.84,1.23) 1.08 (0.71,1.64) 0.99 (0.74,1.33) 1.00 (0.76,1.32) 1.05 (0.73,1.52)
PDR vs DWR   1.26 (1.02,1.56)* 1.60 (1.01,2.52)* 1.32 (0.93, 1.87) 1.38 (0.99,1.92) 1.32 (0.91,1.92)
UCP2 rs659366    A vs G AA vs GG GA vs GG AA+GA vs GG AA vs GA + GG
NPDR vs DWR   1.36 (0.69,2.67) 2.48 (0.33, 18.37) 2.33 (0.51,10.57) 2.35 (0.45, 12.43) 1.26 (0.58,2.75)
PDR vs DWR   1.17 (0.67,2.05) 1.40 (0.46,4.24) 1.17 (0.57,2.40) 1.22 (0.54,2.77) 1.28 (0.63,2.56)
UCP1 rs1800592    G vs A GG vs AA AG vs AA GG + AG vs AA GG vs AG + AA
DR vs DWR Chinese 1.05 (0.94, 1.16) 1.12 (0.89,1.40) 1.00 (0.82,1.22) 1.04 (0.86,1.26) 1.12 (0.93,1.35)
  Total 1.03 (0.93, 1.13) 1.10 (0.88,1.37) 1.00 (0.84,1.19) 1.03 (0.87,1.21) 1.11 (0.92, 1.33)
UCP2 rs659366    A vs G AA vs GG GA vs GG AA+GA vs GG AA vs GA + GG
DR vs DWR Chinese 0.99 (0.74, 1.34) 1.20 (0.52,2.76) 1.13 (0.70,1.83) 1.15 (0.65,2.03) 1.08 (0.65,1.77)
  Total 1.00 (0.79,1.27) 1.17 (0.63,2.17) 1.10 (0.79,1.55) 1.12 (0.75,1.67) 1.07 (0.73,1.57)
  1. *P < 0.05, DWR diabetes without retinopathy, DR diabetic retinopathy, PDR proliferative diabetic retinopathy, NPDR non-proliferative diabetic retinopathy, C.I. confident interval
\