Development and validation of a nomogram to predict cancer-specific survival of uveal melanoma

BMC Ophthalmology

Table 2 Univariate and multivariate analysis of factors's ability to predict CSS in the training cohort

		Univarable analysis		Multivariate analysis
		SHR (95% CI)	P-value	SHR (95% CI)	P-value
Age			0.001*		0.003*
	≤58	Ref		Ref
	> 58	1.748 (1.256–2.433)		1.679 (1.186–2.375)
Gender			0.377
	Female	Ref
	Male	1.150 (0.844–1.567)
Race			0.675
	White	Ref
	Black	0.428 (0.058–3.176)
	Other	0.791 (0.187–3.347)
Marriage			0.563
	Married	Ref
	Unmarried	1.074 (0.771–1.495)
	Unknown	1.330 (0.786–2.253)
Insurance			0.282
	Medicaid	Ref
	Insured	0.726 (0.422–1.250)
	Uninsured	1.351 (0.551–3.311)
	Unknown	0.916 (0.267–3.146)
Primary site			0.026*		0.247
	Chorioid	Ref		Ref
	Cilliary body and iris	1.568 (1.055–2.331)		1.296 (0.835–2.011)
Laterality			0.569
	Left	Ref
	Right	1.093 (0.804–1.489)
Histological type			< 0.001*
	Spindle cell melanoma	Ref		Ref
	Mixed epithelioid and spindle cell melanoma	3.899 (2.014–7.547)		2.593 (1.311–5.130)	0.006*
	Epithelioid cell melanoma	4.276 (1.924–9.504)		3.107 (1.315–7.301)	0.010*
	Other	2.120 (1.150–3.910)		2.128 (1.093–4.142)	0.026*
T stage			< 0.001*
	T1	Ref		Ref
	T2	1.478 (0.749–2.917)		1.427 (0.724–2.813)	0.305
	T3	4.389 (2.394–8.045)		4.059 (2.205–7.471)	< 0.001*
	T4	8.110 (4.464–14.736)		5.135 (2.675–9.856)	< 0.001*
N stage			< 0.001*		0.666
	N0	Ref		Ref
	N1	10.163 (3.565–28.969)		0.770 (0.235–2.520)
M stage			< 0.001*		< 0.001*
	M0	Ref		Ref
	M1	15.074 (8.645–26.283)		11.531 (5.115–25.992)
Surgery			< 0.001*		0.961
	No	Ref		Ref
	Yes	1.869 (1.366–2.556)		1.018 (0.511–2.028)
Radiotherapy			< 0.001*		0.479
	No	Ref		Ref
	Yes	0.512 (0.376–0.698)		0.776 (0.385–1.565)
Chemotherapy			0.023*		0.213
	No	Ref		Ref
	Yes	2.301 (1.119–4.731)		0.512 (0.179–1.467)

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