Fig. 1

Representative case of a 42-year-old man with chronic central serous chorioretinopathy. Fundus images of the left eye obtained pre-treatment (a–c, d, e), 1 month (f, g), and 6 months after treatment (h, i), who were treated with half-dose verteporfin photodynamic therapy. a The fundus photograph shows serous retinal detachment with 1-disc-diameter size at the fovea (yellow arrow). b Early-phase fluorescein angiography (FA) shows leakage at the nasal side of the fovea (red arrow). c The middle-phase of indocyanine green angiography (ICGA) shows diffuse choroidal hyperpermeability at correspondence with leaking spots on FA (white arrow). d-h Laser speckle flowgraphy (LSFG) and horizontal sectional optical coherence tomography (OCT) images. d, e The red and yellow areas on LSFG represent a relatively high mean blur rate (MBR) at the macular area, which corresponds to the area of hyperpermeability on ICGA. OCT shows serous retinal detachment at the macula (blue double arrow) and a thickened choroid (red dash double arrow, 596 μm). f, g LSFG shows fewer red and yellow areas, which indicate a reduction in choroidal blood flow. Serous retinal detachment at the macula disappeared with choroidal thinning (558 μm) 1 month and 6 months (555 μm) after treatment