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Table 1 Effect of topical dorzolamide, benzalkonium-preserved dorzolamide, and benzalkonium-preserved brinzolamide on the advanced oxidation protein products (AOPP) and total sulfhydryl (-SH) groups content in the tear film

From: Impact of dorzolamide, benzalkonium-preserved dorzolamide and benzalkonium-preserved brinzolamide on selected biomarkers of oxidative stress in the tear film

Parameter/group

C

DL

DL+BAC

BL+BAC

AOPP [nmol/mg protein]

3.64 ± 0.21

3.70 ± 0.23

4.43 ± 0.21*

4.33 ± 0.18*

Total -SH groups [μmol/ml]

0.731 ± 0.018

0.698 ± 0.016

0.663 ± 0.014*

0.664 ± 0.012*

  1. C - control group (n = 25); DL - patients with glaucoma using topical dorzolamide (n = 14); DL+BAC - patients with glaucoma using topical dorzolamide + benzalkonium chloride (BAC) (n = 16); BL+BAC - patients with glaucoma using topical brinzolamide + BAC (n = 17)
  2. Results are presented as means ± SEM. * p < 0.05 - statistically significantly different from the C group
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BMC Ophthalmology

ISSN: 1471-2415

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