Table 4 Genotypes of the Keratoconus and Control Groups Determined in This Study
dbSNP identification number and related gene | Genotype | Number of subjects with the corresponding genotype, (%) | Chi-squared test p-value | ||||
|---|---|---|---|---|---|---|---|
Keratoconus group | Main control group | Additional control group | Keratoconus group | Main control group | Additional control group | ||
rs1536482 (near COL5A1 gene) | A/A | 24 (16.0) | 16 (7.8) | 42 (8.4) | 0.7860 | 0.9580 | 0.5653 |
G/A | 70 (46.7) | 82 (40.0) | 207 (41.2) | ||||
G/G | 56 (37.3) | 107 (52.2) | 225 (44.8) | ||||
rs2721051 (near FOXO1 gene) | T/T | 2 (1.3) | 1 (0.5) | 4 (0.8) | 0.8824 | 0.7061 | 0.3739 |
C/T | 33 (22.0) | 22 (10.7) | 63 (12.5) | ||||
C/C | 115 (76.7) | 182 (88.8) | 407 (80.9) | ||||
rs1324183 (near the MPDZ gene) | A/A | 0 (0.0) | 11 (5.4) | 17 (3.7)a | 0.1795 | 0.2216 | 0.0480 |
A/C | 23 (15.3) | 60 (29.3) | 111 (24.0)a | ||||
C/C | 127 (84.7) | 134 (65.3) | 334 (72.3)a | ||||