Association of four gene polymorphisms in Chinese Guangxi population with diabetic retinopathy in type 2 diabetic patients

Table 2 Analysis of 4 SNPs in NDR and PDR groups

Gene	SNP	Allele	NDR [%]	PDR [%]	Geno-type	NDR [n (%)]	PDR [n (%)]	χ² test	Logistic regression analysis
Gene	SNP	Allele	NDR [%]	PDR [%]	Geno-type	NDR [n (%)]	PDR [n (%)]	P-value	odds ratio (95% CI)	P_adjust-value
IL-10	rs1800896	T	95.85	90.71	TC	32 (8.29)	50 (16.03)	0.002	2.366 (1.144, 4.894)	0.020
		C	4.15	9.29	CC	0 (0)	4 (1.28)	0.026	1.524 (0)	0.999
					TT	354 (91.71)	258 (82.69)	0.001	Reference
					Total	386	312
VEGFA	rs2010963	C	39.00	34.62	CG	214 (56.02)	140 (44.87)	0.003	0.588 (0.366, 0.946)	0.028
		G	60.99	65.38	CC	42 (10.99)	38 (12.18)	0.627	1.277 (0.578, 2.821)	0.546
					GG	126 (32.98)	134 (42.95)	0.007	Reference
					Total	382	312
RAGE	rs2070600	C	72.80	82.00	CC	200 (51.81)	200 (66.67)	0.001	Reference
		T	27.20	18.00	TT	24 (6.22)	8 (2.67)	0.029	0.180 (0.037, 0.872)	0.033
					CT	162 (41.97)	92 (30.67)	0.002	0.448 (0.266, 0.753)	0.002
					Total	386	300
miR-146a	rs2910164	C	63.68	65.88	CC	158 (41.58)	132 (44.59)	0.432	–
		G	36.32	34.12	GG	54 (14.21)	38 (12.84)	0.606	–
					CG	168 (44.21)	126 (42.57)	0.669	–
					Total	380	296

Bold indicates statistically significant results
P_adjust values were adjusted for systolic blood pressure and using insulin treatment and glomerular filtration rate (GFR)

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