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Table 2 Cytokine profile (pg/mL, mean ± SD) and correlation between the concentration of cytokines and vascular endothelial growth factor (VEGF)

From: Aqueous humor cytokine levels through microarray analysis and a sub-analysis based on optical coherence tomography in wet age-related macular degeneration patients

 

wAMD group (n = 13)

Control group (n = 10)

p*

Correlation coefficient r

p

IL-1α

40.54 ± 56.07

16.2 ± 11.88

0.278

0.46

0.028

IL-1β

7.6 ± 16.30

2.3 ± 3.69

0.734

0.76

0.001

IL-2

17.5 ± 12.99

11.6 ± 7.82

0.395

0.44

0.038

IL-4

10.3 ± 13.6

6.6 ± 4.04

0.962

0.56

0.009

IL-5

8.8 ± 7.99

9.2 ± 4.92

0.285

0.40

0.058

IL-6

24.4 ± 10.65

33.1 ± 11.19

0.095

0.64

0.002

IL-8

29.6 ± 32.62

19.1 ± 8.87

0.427

0.36

0.088

IL-10

2.6 ± 1.83

2.6 ± 1.06

0.792

0.70

0.001

IL-12p70

3.7 ± 4.77

2.3 ± 1.35

0.734

0.43

0.047

IL-13

9.3 ± 4.80

10.2 ± 2.72

0.193

0.52

0.014

GM-CSF

28.3 ± 12.98

33.6 ± 20.71

0.734

0.37

0.076

GRO

457.4 ± 215.28

381.1 ± 149.52

0.277

0.23

0.272

IFN-γ

293.1 ± 103.77

317.3 ± 114.59

0.651

0.21

0.329

MCP-1

951.8 ± 265.13

540.3 ± 261.01

0.003

−0.03

0.903

MIP-1α

679.1 ± 525.50

263.3 ± 226.85

0.041

−0.51

0.807

MIP-1β

32.9 ± 27.1

11.4 ± 10.1

0.034

0.29

0.180

MMP-9

151.4 ± 111.58

108.1 ± 79.15

0.343

0.18

0.393

RANTES

2.9 ± 3.76

0.9 ± 0.59

0.343

0.65

0.002

TNFα

977.0 ± 401.35

1140.8 ± 377.42

0.310

0.44

0.038

VEGF

236.2 ± 196.31

106.3 ± 30.41

0.009

  1. wAMD wet age-related macular degeneration
  2. *Mann-Whitney U test
  3. Spearman’s rank correlation