Table 3 Incidence rate and hazard ratio of PD between with and without age-related macular degeneration stratified by sex, age, comorbidity, numbers of comorbidity, and medication

 Female

115

28,927

3.98

191

29,623

6.45

1.62 (1.29–2.04)***

1.42 (1.13–1.80)**

 Male

160

28,240

5.67

242

29,385

8.24

1.45 (1.19–1.78)***

1.28 (1.05–1.57)*

 50–59

9

10,684

0.84

18

10,445

1.72

2.05 (0.92–4.56)

1.31 (0.57–3.01)

 60–69

60

18,836

3.19

100

18,814

5.32

1.67 (1.21–2.30)**

1.51 (1.09–2.09)*

 70–79

148

20,681

7.16

216

22,159

9.75

1.36 (1.10–1.68)**

1.30 (1.05–1.60)*

 80–100

58

6967

8.32

99

7589

13.0

1.57 (1.14–2.17)**

1.40 (1.01–1.95)*

 Osteoporosis

51

9755

5.23

131

13,631

9.61

1.82 (1.32–2.52)***

1.68 (1.22–2.33)**

 Diabetes

109

18,056

6.04

222

26,020

8.53

1.41 (1.12–1.78)**

1.41 (1.12–1.78)**

 Cirrhosis

94

15,195

6.19

169

22,003

7.68

1.25 (0.97–1.60)

1.20 (0.93–1.54)

 Cerebrovascular disease

92

9742

9.44

159

13,324

11.93

1.27 (0.98–1.64)

1.25 (0.96–1.62)

 Chronic kidney disease

18

1942

9.27

27

2904

9.30

1.02 (0.56–1.85)

0.99 (0.54–1.81)

 Hypertension

206

33,161

6.21

357

40,520

8.81

1.41 (1.19–1.68)***

1.36 (1.15–1.62)***

 Hyperlipidemia

86

15,963

5.39

156

22,973

6.79

1.27 (0.97–1.65)

1.17 (0.90–1.52)

 Coronary artery disease

23

2596

8.86

36

3965

9.08

1.02 (0.60–1.71)

1.01 (0.59–1.70)

 Chronic obstructive pulmonary disease

117

16,690

7.01

192

22,017

8.72

1.25 (0.99–1.57)

1.19 (0.94–1.50)

 0

28

12,790

2.19

13

6184

2.10

0.95 (0.49–1.84)

0.95 (0.49–1.85)

  ≥ 1

247

44,378

5.57

420

52,823

7.95

1.43 (1.22–1.67)*

1.40 (1.20–1.64)***

 Statin

208

44,636

4.66

332

44,596

7.44

1.60 (1.34–1.90)***

1.42 (1.19–1.69)***

 CCB

207

42,835

4.83

329

44,916

7.32

1.52 (1.27–1.80)***

1.32 (1.11–1.58)**