Table 1 Demographic features and baseline clinical characteristics of patients with IgG4-RD

Male (%)

62.30%

75.30%

51.60%

< 0.001

Age, years (median, IQR)

56 (47, 63)

59 (52,66)

53 (45,60)

< 0.001

Time to diagnosis, months (median, IQR)

12 (5, 36)

8 (3,24)

24 (12,52)

< 0.001

Score of ACR/EULAR classification criteria (median, IQR)

29 (25, 37)

27 (22,34)

31 (25,39)

< 0.001

IgG4-RD RI (median, IQR)

12 (6, 15)

12 (6,15)

12 (9,15)

< 0.001

 Nausea and vomiting

48 (8.4)

31 (12.1)

17 (5.4)

0.005

 Parotid gland swelling

76 (13.3)

18 (7)

58 (18.1)

< 0.001

 Submandibular gland swelling

264 (46.3)

83 (32.3)

181 (57.8)

< 0.001

 Lymphadenopathy

138 (24.2)

56 (21.8)

82 (26.2)

0.222

 Abdominal pain

95 (16.7)

72 (28)

23 (7.3)

< 0.001

 Jaundice

92 (16.1)

71 (27.6)

21 (6.7)

< 0.001

 Nasal congestion

98 (17.2)

23 (8.9)

75 (24)

< 0.001

 Cough

57 (10)

29 (11.3)

28 (8.9)

0.354

 Low back pain

30 (5.3)

16 (6.2)

14 (4.5)

0.351

 Fever

28 (4.5)

19 (7.4)

9 (2.9)

0.013

Allergy history, n (%)

294 (51.3)

96 (37.1)

198 (63.1)

< 0.001

Number of organs involved, n (%)

< 0.001

 1–2

165 (28.8)

109 (42.1)

56 (17.9)

 3–4

251 (43.9)

109 (42.1)

142 (45.4)

  ≥ 5

156 (27.3)

41 (15.8)

115 (36.7)

 Salivary gland

370 (64.6)

115 (44.4)

255 (81.2)

< 0.001

 Pancreas

233 (40.7)

150 (57.9)

83 (26.4)

< 0.001

 Biliary system

137 (23.9)

97 (37.5)

40 (12.7)

< 0.001

 Retroperitoneal fibrosis

61 (10.6)

45 (17.4)

16 (5.1)

< 0.001

 Lung

148 (25.8)

59 (22.8)

89 (28.3)

0.130

 Kidney

73 (12.7)

31 (12)

42 (12.4)

0.615

 Lymph node

261 (45.5)

115 (44.4)

146 (46.5)

0.616

 Sinusitis

165 (28.8)

31 (12)

134 (42.7)

< 0.001

 Prostate

51 (8.9)

33 (12.7)

18 (5.7)

0.003

 Thyroid gland

15 (2.6)

8 (3.1)

7 (2.2)

0.521

 Gastrointestinal tract

10 (1.7)

7 (2.7)

3 (1.0)

0.198

Serum IgG4 elevation, n (%)

524 (93.8)

233 (90.3)

301 (96.8)

0.001