Fig. 7

GLI represses inflammation and oxidative injury in retinal tissues of DM rats via SIRT1/Notch1 pathway. (A) The level of IL-β in retina of DM rat after GLI administration was measured by ELISA assay. (B) The level of TNF-α in retina of DM rat after GLI administration was measured by ELISA assay. (C) The level of IL-6 in retina of DM rat after GLI administration was measured by ELISA assay. (D) The level of ROS in retina of DM rat after GLI administration was measured by a commercial kit. (E) The level of CAT in retina of DM rat after GLI administration was measured by a commercial kit. (F) The level of SOD in retina of DM rat after GLI administration was measured by a commercial kit. (G) The protein levels of SIRT1, Notch1, Hes1, and Hey2 in retina of DM rat after GLI administration was determined by western blotting. **P < 0.01 vs. the normal group. ^##P < 0.01 vs. the DM group. GLI: 50 mg/kg body weight gliquidone