Fig. 4

Representative fluorescein angiography (FA) images in refractory group with localized FA leakage over central macula. A FA images at 1 min. B FA images at 5 min. The large and small squares demarcated by yellow dashed line denote the locations of perifoveal and parafoveal images, respectively. C Binarized FA images of the perifoveal area at 1 min. The yellow crosses indicate the location of the foveal centers. D Binarized FA images of the perifoveal area at 5 min. E Perifoveal images after subtracting the image at 1-min from the image at 5-min. The mean gray value over the perifoveal region was 16.1. F Binarized FA images of the parafoveal area at 1 min. G Binarized FA images of the parafoveal area at 5 min. H Parafoveal images after subtracting the image at 1-min from the image at 5-min. The mean gray value over the parafoveal images was 27.2. I Pre-treatment coherence tomography (OCT) images with central retinal thickness (CRT) of 345 μm