Fig. 4

A: In vivo confocal microscopy of the corneal graft for representative case #5 at 1 month after the therapeutic penetrating keratoplasty. No corneal endothelial cells were detected on the posterior surface of the graft. B: In vivo confocal microscopy of the corneal graft for representative case #5 at 3 months after the therapeutic penetrating keratoplasty. A newly reconstructed corneal endothelium on the donor graft is observed, with markedly varied cell size and morphology, extraordinarily large cells containing multiple nuclei (triangle) and cell division (arrow). The cell density of the regenerated endothelium was 1186 cells/mm² at this time. C: In vivo confocal microscopy of the corneal graft for representative case #5 at 11 months after the therapeutic penetrating keratoplasty. Corneal endothelial cell density of the endothelium on the graft became comparatively consistent in cell morphology and size. The cell density of the regenerated endothelium reached 1686 cells/mm² at this time