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Table 1 Characteristics of corneal endothelial regeneration on donor grafts after therapeutic penetrating keratoplasty

From: Corneal endothelial regeneration in human eyes using endothelium-free grafts

Patient

No

Gender/Age

(year)

Primary Disease

Reason requires T-PKP

Graft Characteristics

Changes of Graft after Surgery

Additional Ops

BCVA

Follow-up

(Month)

Centricity

Size

(mm)

Earliest detectable ECs

(Month)

Shift to complete clear

(Month)

Final

EC density

(cells/mm2)

 

Pre-op

Last

 

1

M/47

FK

Perforation & severe intraocular inflammation

centric

7.75

2.5

10

814

Phaco+IOL implant

LP

1.0

207

Laser posterior capsulectomy

2

M/35

Thermal Burn

Corneal perforation

Centric

7.75

1.5

2.5

1148

CLAU

HM

0.2

36

3

M/55

FK

Corneal perforation

Centric

8.0

3

5

875

none

FC

0.5

16

4

M/27

HSK

Corneal perforation

Eccentric

8.25

1

2

1531

none

HM

0.8

19

5

M/28

FK

Corneal perforation & severe intraocular inflammation

Centric

8.0

3

11

1340

none

HM

0.8

19

6

F/61

HSK

Large tear of DM, scheduled DALK shifted to temporary PK using cryopreserved tissue

Centric

7.75

4

7.5

819

none

FC

0.3

26

7

M /21

Keratoconus, Acute corneal hydrops

Large tear of DM, scheduled DALK shifted to temporary PK using cryopreserved tissue

Centric

8.0

1

6.5

1030

none

FC

0.9

37

8

F/22

Phlyctenular keratoconjunctivitis

Corneal perforation

Eccentric

7.5

3

6

848

none

0.4

0.7

20

9

M/65

HSK

Corneal perforation

Centric

8.0

1.5

10

853

ECCE+IOL

FC

0.2

12.5

10

M/22

Keratoconus

Large tear of DM, scheduled DALK shifted to temporary PK using cryopreserved tissue

Centric

7.75

1.5

2.5

782

none

0.1

0.6

38

11

M/48

Thermal Burn

Corneal perforation

Centric

8.0

3

7

1126

AMT + CLAU

HM

0.3

36

12

M/47

Thermal Burn

Corneal melting, perforation, prolapse of intraocular contents

Eccentric involving partial limbal area

7.0

2

6.5

939

AMT + CLAU

LP

0.2

24

13

M/48

HSK

Corneal perforation

Eccentric

7.5

3

8

1208

non

LP

0.5

168

14

M/16

Phlyctenular keratoconjunctivitis

Large tear of DM, scheduled DALK shifted to temporary PK using cryopreserved tissue

Centric

8.0

1

3

873

none

0.3

0.7

36

15

M/25

Keratoconus, Acute corneal hydrops

Large tear of DM, scheduled DALK shifted to temporary PK using cryopreserved tissue

Centric

7.5

3

5

882

none

FC

0.8

30

16

F/18

Trauma, Corneal laceration, Large tissue defect

Corneal perforation & laceration

Eccentric involving partial limbal area

9.5

1.5

5

859

CLAU

FC

0.2

72

17

F/15

Keratoconus, Acute corneal hydrops

Large tear of DM, scheduled DALK shifted to temporary PK using cryopreserved tissue

Centric

8.25

2

3.5

900

none

0.05

1

50.5

18

F/22

HSK

Large tear of DM, scheduled DALK shifted to temporary PK using cryopreserved tissue

Centric

8.0

3

5.5

1002

none

FC

0.1

20

  1. T-PKP therapeutic penetrating keratoplasty, Ops operations, EC endothelial cell, FK fungal keratitis, HSK herpes simplex keratitis, BCVA best-corrected visual acuity, CLAU conjunctiva limbal autograft, HM hand motion, LP light perception, AMT amniotic membrane transplantation, ALT Allogeneic limbal transplantation. The size of the graft was 0.5 mm larger than the size of host trephination