Table 1 Distributions of demographic and clinical comorbid variables in study cohorts

N

%

n

%

N

%

P-value

Age, years

< 0.001

  >50

22,758

30.8

18,149

32.6

4609

25.3

  50–64

28,749

38.9

20,875

37.5

7874

43.2

  65+

22,457

30.4

16,722

30.0

5735

31.5

  Mean ± SD ^a

57.2

13.8

56.8

14.3

58.6

12.1

< 0.001

Sex

< 0.001

  Female

35,841

48.5

27,310

49.0

8531

46.8

  Male

38,123

51.5

28,436

51.0

9687

53.2

Comorbidity

  Hypertension

50,266

68.0

35,537

63.8

14,729

80.9

< 0.001

  Dyslipidemia

49,730

67.2

36,311

65.1

13,419

73.7

< 0.001

  Diabetic nephropathy

7642

10.3

4776

8.57

2866

15.7

< 0.001

  Diabetic neuropathy

1235

1.67

717

1.29

518

2.84

< 0.001

  Heart disease

31,067

42.0

20,884

37.5

10,183

55.9

< 0.001

  Cardiovascular disease

9649

13.1

6105

11.0

3544

19.5

< 0.001

  Peripheral arteriolar disease

6120

8.27

4258

7.64

1862

10.2

< 0.001

Medication

  Statin

35,075

47.4

24,464

43.9

10,611

58.2

< 0.001

  Fibrate

22,313

30.2

15,800

28.3

6513

35.8

< 0.001

  ACEI

38,899

52.6

27,032

48.5

11,867

65.1

< 0.001