Effect of anticoagulant/antiplatelet therapy on the development and progression of diabetic retinopathy

BMC Ophthalmology

Table 5 Cox proportional hazard regression analysis for the risk of NPDR -associated Aspirin with combined effect of APACS

Variables		N	Event n	Adjusted HR^a (95% CI)	p-value^#
Aspirin	Clopidogrel				0.36
No	No	59,329	4704	1(Reference)
No	Yes	1194	81	0.85(0.68, 1.06)
Yes	No	12,325	1000	0.82(0.76, 0.88)***
Yes	Yes	1116	60	0.57(0.44, 0.74)***
Aspirin	Ticlopidine				0.34
No	No	59,984	4739	1(Reference)
No	Yes	539	46	1.01(0.76, 1.36)
Yes	No	13,079	1038	0.81(0.76, 0.87)***
Yes	Yes	362	22	0.59(0.39, 0.90)*
Aspirin	Warfarin				0.88
No	No	60,084	4758	1(Reference)
No	Yes	439	27	0.79(0.54, 1.15)
Yes	No	13,172	1045	0.81(0.75, 0.87)***
Yes	Yes	269	15	0.59(0.35, 0.98)*
Aspirin	Dipyridamole				0.12
No	No	58,000	4559	1(Reference)
No	Yes	2523	226	0.85(0.74, 0.97)*
Yes	No	11,534	932	0.83(0.77, 0.89)***
Yes	Yes	1907	128	0.61(0.51, 0.73)***

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