Skip to main content

Table 2 Studies measuring vitreous and serum biomarker levels in DR patients compared to controls

From: Correlation between the progression of diabetic retinopathy and inflammasome biomarkers in vitreous and serum – a systematic review

  

Vitreous

Serum

 

Biomarker

Increased

Not changed

Decreased

Increased

Not changed

Decreased

Pro-inflammatory

VEGF

[40, 58]

  

[48, 51, 53]

[40, 45, 49]

 

IL-1β

[43, 58]

  

[41, 48]

[49] [54]

 

IL-18

[43]

  

[47]

  

TNF-α

[42, 58]

[40]

 

[41, 42, 46, 48, 51, 59] [54]

[40, 49]

 

ET-1

[58]

     

IL-6

[40, 42, 58]

  

[40,41,42, 44, 48, 49, 54, 59]

  

IL-4

 

[40]

  

[40, 49] [54]

 

IL-2

 

[40]

  

[40, 49]

 

IFN-γ

 

[40]

 

[41]

[40, 49]

 

IL-2R

   

[46]

  

sIL-6R

   

[44]

  

sgp130

   

[44]

  

NO

   

[46]

  

IL-17A

   

[54, 54]

  

IL-1α

    

[49]

 

MIP-1α

    

[53]

 

CRP

   

[51, 59]

  

IL-12

   

[41, 47]

 

[54]

Anti-inflammatory

BNDF

  

[40]

  

[40]

LXA4

  

[40]

  

[40]

IL-10

[40]

[58]

 

[41]

[40, 49]

 

PEDF

[40]

  

[52]

[40]

 

IL-22

    

[55]

 

IL-27

 

[57]

   

[57]

IL-35

  

[57]

  

[57]

Chemotactic

VCAM-1

[42]

  

[39, 42]

  

ICAM-1

[42]

  

[42]

  

MCP-1/ CCL2

[58]

  

[50, 53]

[41, 49]

 

IL-8

[58]

  

[41, 46, 49]

[53, 54]

 

sE-selectin

   

[39]

  

IP-10

   

[47]

  

Cell growth

IGF-1

     

[45]

EGF

    

[49, 53]

 
  1. BDNF brain derived neurotrophic factors, CRP C reactive protein, EGF epidermal growth factor, ICAM-1 intercellular adhesion molecule-1, IFN-γ interferon gamma, IGF-1 Insulin-like growth factor 1, IL interleukin, IL-1Rα Interleukin-1 receptor alpha, IP-10 Interferon-Inducible Protein 10, LXA4 lipoxin A4, MIP-1α macrophage inflammatory protein, MCP-1/CCL2 monocyte chemoattractant protein-1/chemokine (C–C motif) ligand 2, NO nitric oxide, PEDF pigment epithelium derived factor, sgp130 soluble glycoprotein 130, TNF-α tumor necrosis factor-alpha, VCAM-1 vascular cell adhesion molecule-1, VEGF vascular endothelium growth factor