Table 2 Evolution of the studied parameters during and after IPL treatment between D0 and D45 (end of IPL treatment), D0 and 3rd month and D0 and 6th month. Longitudinal evolution of studied parameters values was assessed using a likelihood ratio test. P-values of the non-parametric test are provided between brackets

NIBUT

Baseline

Delta D0 - D45

Delta D0 – M3

Delta D0 – M6

8.9090 seconds

[8.2; 9.7]

P value of the likelihood ratio test = 0.0161

1.1030 seconds

[0.5; 2.1]

1.6267 seconds

[0.5; 2.6]

1.1265 seconds

[0.5; 2.2]

P value of the non-parametric test = 0.0091

OSDI

Baseline

D0 - D45

D0 – M3

D0 – M6

44.152

[38.3; 49.6]

P value of the likelihood ratio test = 0.0124

−6.761

[−12.3; −1.3]

−7.379

[− 13.2; − 1.6]

−9.244

[− 15.3; −3.6]

P value of the non-parametric test = 0.0035

Oxford score

Baseline

D0 - D45

D0 – M3

D0 – M6

1.600

[−1.4; 1.8]

P value of the likelihood ratio test = 0.00021

−0.4056

[−0.6; −0.2]

− 0.4005

[− 0.7; − 0.2]

−0.4414

[− 0.7; − 0.2]

P value of the non-parametric test = 3*10^-5

Interferometry

Baseline

D0 - D45

D0 – M3

D0 – M6

43.133

[37.1; 49.1]

P value of the likelihood ratio test = 0.0315

−7.840

[−14.2; − 1.4]

−8.260

[−14.9; − 1.7]

−6.880

[−13.9; 0.2]

P value of the non-parametric test = 0.1830

BUT

Baseline

D0 - D45

D0 – M3

D0 – M6

15.6333

[14.2; 17.2]

P value of the likelihood ratio test = 0.0406

0.8333

[−0.8; 2.5]

−1.3503

[−3.2; 0.5]

−1.3142

[− 3.2; 0.5]

P value of the non-parametric test = 0.0132

Schirmer test

Baseline

D0 - D45

D0 – M3

D0 – M6

13.7479

[11.7; 16.1]

P value of the likelihood ratio test =0.9764

−0.3238

[−2.1; 1.5]

−0.0746

[−2.0; 1.8]

0.1011

[−1.7; 2.1]

P value of the non-parametric test = 0.8303

Tear meniscus

height

Baseline

D0 - D45

D0 – M3

D0 – M6

0.3057

[0.04; 0.6]

P value of the likelihood ratio test = 0.4625

0.2325

[−0.2; 0.6]

−0.006

[−0.4; 0.4]

−0.0503

[−0.4; 0.3]

P value of the non-parametric test = 0.0592