| 12 months | 36 months | 36 months (Caucasian) | 36 months (Non-Caucasian) | p-value |
---|---|---|---|---|---|
No. of eyes | 89 | 89 | 48 | 41 | – |
Mean ± SD final VA, letters | 67.0 ± 16.4 | 63.2 ± 21.0 | 70.5 ± 12.0 | 54.7 ± 25.8 | < 0.001b |
Mean ± SD CRT, microns | 307.3 ± 146.5 | 295.4 ± 122.2 | 269.9 ± 77.0 | 327.0 ± 157.2 | 0.269b |
Mean change in VA letters (95% CI) | + 8.9 (2.7 to 10.5) | + 5.0 (− 2.7 to 8.8) | + 7.6 (3.2 to 12.0) | + 2.0 (− 5.8 to 9.8) | 0.581b |
Proportion with ≥15-letter gain | 24 (27.0%) | 29 (32.6%) | 17 (35.4%) | 12 (29.3%) | 0.651c |
Proportion with ≤15-letter loss | 84 (94.4%) | 78 (87.6%) | 44 (91.7%) | 34 (82.9%) | 0.333c |
VA ≥70 letters (20/40 Snellen equivalent) | 48 (53.9%) | 47 (52.8%) | 33 (68.8%) | 14 (34.1%) | 0.001c |
Mean total ± SD, no. of injections | 5.8 ± 2.9 | 13.8 ± 8.1 | 14.0 ± 8.1 | 13.6 ± 8.1 | 0.833d |
Received PDT, no. (%) | 5 (5.6%) | 14 (15.7%) | 4 (8.3%) | 10 (24.4%) | 0.08c |
Mean time to PDT (SD), months | – | – | 30 (15.2) | 19.1 (15.6) | 0.185d |
Polyp regression, no (%)a | 2/24 (8.3%)- | 12/24 (50.0%) | 7/10 (70.0%) | 5/14 (35.7%) | 0.214c |
Mean time to Polyp Regression (SD), monthsa | – | – | 45.3 (33.5) | 34 (19.9) | 0.519d |
Received Aflibercept or Ranibizumab, no. (%) | 6 (6.7%) | 15 (16.9%) | 11 (22.9%) | 4 (9.8%) | 0.155c |