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Table 2 Comparison of symptoms and signs of MGD patients between different subgroups

From: The lack of correlation between symptoms and signs in patients with meibomian gland dysfunction: a secondary analysis of the multicenter, randomized controlled trial

 

SPEED

Median (IQR)

TBUT

M (IQR)

CFSS

M (IQR)

MGYSS

M (IQR)

a

n (%)

b

n (%)

c

n (%)

d

n (%)

e

n (%)

Total

(n = 122)

14.00(11.75–18.00)

2.77(2.20–3.99)

1.25(0.00–2.00)

4.50(2.50–7.5)

93(76.2)

40(32.8)

40(32.8)

30(24.6)

44(36.1)

Age

  < 40 years (n = 61)

14.00(12.00–18.00)

2.71(2.19–4.05)

1.50(0.00–2.25)

4.50(2.25–7.50)

43(70.5)

8(13.1)

5(8.2)

4(6.6)

15(24.6)

  ≥ 40 years (n = 61)

14.00(11.00–18.00)

2.84(2.26–3.82)

1.00(0.00–2.00)

5.00(2.50–7.75)

50(82.0)

32(52.5)

35(57.4)

26(42.6)

29(47.5)

p

0.463

0.794

0.422

0.424

0.201

<0.0001*

<0.0001*

<0.0001*

0.014*

sex

 Male (n = 27)

13.00(11.00–18.00)

3.14(2.62–4.23)

1.00(0.00–2.00)

5.00(2.50–9.00)

22(81.5)

8(29.6)

11(40.7)

7(25.9)

10(37.0)

 Female (n = 95)

14.00(12.00–18.00)

2.68(2.14–3.80)

1.50(0.50–2.00)

4.50(2.50–6.50)

71(74.7)

32(33.7)

29(30.5)

23(24.2)

34(35.8)

p

0.736

0.059

0.176

0.302

0.611

0.818

0.357

1.000

1.000

Menopause

 No (n = 71)

14.00(12.00–18.00)

2.72(2.22–3.93)

1.50(0.50–2.00)

4.50(2.00–7.00)

49(69.0)

16(22.5)

13(18.3)

11(15.5)

20(28.2)

 Yes (n = 24)

13.50(8.25–18.75)

2.62(2.00–3.42)

1.25(0.00–2.88)

4.75(2.63–6.50)

22(91.7)

16(66.7)

16(66.7)

12(50.0)

14(58.3)

p

0.210

0.555

0.979

0.559

0.031*

 < 0.0001*

 < 0.0001*

0.002*

0.013*

Region

 North (n = 69)

15.00(12.00–19.00)

2.77(2.12–4.05)

1.00(0.00–2.00)

4.50(1.50–7.00)

65(94.2)

36(52.2)

37(53.6)

28(40.6)

32(46.4)

 South (n = 53)

14.00(11.00–17.00)

2.78(2.35–3.67)

1.50(0.00–2.25)

4.50(3.00–7.75)

28(52.8)

4(7.5)

3(5.7)

2(3.8)

12(22.6)

p

0.173

0.895

0.365

0.221

 < 0.0001*

 < 0.0001*

 < 0.0001*

 < 0.0001*

0.008*

  1. SPEED Standard patient evaluation of eye dryness, TBUT Tear break-up time, CFSS Corneal fluorescein staining score, MGYSS Meibomian gland yielding secretion score
  2. a: Lid margin hyperemia, b: Lid margin thickening, c: Lid margin rounding, d: Hyperkeratinization, e: Telangiectasia around orifices
  3. * p < 0.05