Skip to main content

Table 4 The association between hypertensive retinopathy and the UACR by subgroupa

From: Positive correlation between hypertensive retinopathy and albuminuria in hypertensive adults

Subgroup

N

UACR, Median (interquartile range)

Hypertensive retinopathy groups

p for interaction

Normal

Grade 1

Grade 2

Grade 3

 

β (95% CI)

β (95% CI)

β (95% CI)

Sex

      

0.498

 Male

1070

8.3 (6.1,13.2)

ref

2.54(-0.16,5.25)

4.3(0.77,7.82)

8.17(1.15,15.19)

 

 Female

1893

11.8 (8.3,18.7)

ref

0.97(-0.9,2.83)

1.97(-0.57,4.52)

3.48(-1.45,8.41)

 

Age, years

      

0.107

  < 65

1769

10 (7.1,15.7)

ref

0.95(-0.97,2.86)

2.78(0.26,5.29)

1.56(-3.58,6.7)

 

  ≥ 65

1178

11.4 (7.5,19.3)

ref

2.27(-0.28,4.82)

2.24(-1.33,5.81)

10.5(3.94,17.06)

 

BMI, kg/m2

      

0.220

  < 24

1042

10.3 (7.1,16.6)

ref

-0.62(-3.17,1.93)

2.19(-1.31,5.69)

4.3(-2.53,11.12)

 

  ≥ 24, < 28

1178

10.3 (7.2,16.7)

ref

1.97(-0.42,4.35)

3.5(0.29,6.72)

6.15(-0.44,12.75)

 

  ≥ 28

728

11.2 (7.6,18.3)

ref

3.15(-0.11,6.41)

1.48(-2.72,5.67)

6.54(-1.4,14.49)

 

Treatment group

      

0.380

 Enalapril

1255

10.3 (7.1,16.5)

ref

0.37(-1.69,2.43)

1.85(-0.91,4.61)

7.55(1.53,13.58)

 

 Enalapril + folic acid

1222

10 (7,15.7)

ref

2.72(0.31,5.13)

4(0.76,7.25)

5.06(-0.81,10.94)

 

SBP, mmHg

      

0.402

  < 140

1686

9.5 (6.8,14.9)

ref

1.2(-0.67,3.07)

2.97(0.39,5.56)

1.74(-3.76,7.24)

 

  ≥ 140

1246

11.9 (8.1,20.2)

ref

2.05(-0.55,4.64)

2.47(-0.88,5.83)

8.49(2.51,14.48)

 

TG, mmol/L

      

0.023

  < 1.7

1722

10.1 (7,15.9)

ref

0.21(-1.64,2.06)

1.19(-1.34,3.73)

7.59(2.8,12.37)

 

  ≥ 1.7

1201

11.1 (7.7,18.6)

ref

3.17(0.53,5.81)

4.7(1.25,8.15)

0.13(-7.04,7.31)

 

TCHO, mmol/L

      

0.353

  < 5.2

1259

10.2 (7.2,16.5)

ref

2.06(-0.1,4.22)

2.7(-0.34,5.74)

8.94(3.18,14.7)

 

  ≥ 5.2

1642

10.7 (7.2,17.5)

ref

0.92(-1.24,3.07)

2.64(-0.16,5.45)

1.76(-3.86,7.38)

 

FBG, mmol/L

      

0.251

  < 7.0

2393

10 (7.1,15.7)

ref

0.89(-0.68,2.46)

2.42(0.28,4.55)

3.87(-0.76,8.51)

 

  ≥ 7.0

508

13.8 (8.4,23.4)

ref

4.22(-0.76,9.2)

3.17(-3.13,9.46)

9.2(0.04,18.37)

 

HCY, μmol/L

      

0.882

  < 10

686

10.5 (7.7,17.9)

ref

0.65(-2.4,3.7)

0.8(-3.37,4.96)

9.38(0.31,18.44)

 

  ≥ 10, < 15

1554

10.4 (7.2,16.8)

ref

1.55(-0.54,3.64)

2.44(-0.43,5.31)

3.67(-1.52,8.86)

 

  ≥ 15

678

10.3 (7.1,16.8)

ref

1.75(-1.67,5.17)

3.77(-0.57,8.12)

5.4(-4.26,15.06)

 

Hyperuricemia

      

0.432

 No

2303

10.5 (7.2,17.2)

ref

1.72(0.04,3.41)

2.13(-0.17,4.43)

5.61(1.03,10.2)

 

 Yes

624

10.3 (7.1,16.7)

ref

0.82(-2.87,4.5)

4.05(-0.6,8.71)

3(-5.59,11.58)

 

Smoking status

      

0.014

 Never

2094

11.3 (7.8,18.3)

ref

0.67(-1.09,2.43)

1.77(-0.62,4.16)

2.46(-2.12,7.03)

 

 Former

284

8.9 (6.5,14.1)

ref

3.54(-2.08,9.17)

4.79(-2.65,12.24)

-5.3(-20.25,9.65)

 

 Current

569

8.7 (6.2,14.1)

ref

2.5(-1.22,6.23)

4.64(-0.13,9.42)

18.73(8.47,29)

 

Alcohol consumption

      

0.447

 Never

2089

11.1 (7.8,18.1)

ref

1.05(-0.68,2.77)

2.14(-0.2,4.47)

4.11(-0.38,8.6)

 

 Former

168

9 (6.7,19.5)

ref

4.56(-4.69,13.81)

3.29(-8.53,15.11)

11.04(-17.93,40.01)

 

 Current

575

9 (6.2,14.5)

ref

1.43(-2.05,4.9)

4.24(-0.29,8.77)

5.93(-3.35,15.2)

 
  1. UACR Urinary albumin to creatinine ratio, CI Confidence intervals, BMI Body mass index, SBP Systolic blood pressure, TG Triglyceride, TCHO Total cholesterol, FBG Fasting blood glucose, HCY Homocysteine
  2. aAdjusted for age, sex, body mass index, systolic blood pressure, diastolic blood pressure, methylenetetrahydrofolate reductase C677T polymorphisms, total cholesterol, triglycerides, fasting blood glucose, estimated glomerular filtration rate, folate, homocysteine, smoking status, alcohol consumption, and the use of antihypertensive drugs