Fig. 4

All possible mechanisms related to acute central vision loss after IOP rise due to NVG in patients with PDR. Diabetes mellitus and several other systemic conditions are factors that make NVG patients more susceptible to retinal ischemia. IOP rise due to NVG can accelerate the progression of glaucomatous optic neuropathy and diabetic retinopathy. In addition, especially in group 1, sustained extremely increased IOP may restrict the retinal blood flow through ONH and inner retinal circulation. Since the blood flow autoregulation is effective over only a narrow critical range normally, under the high IOP, the retinal blood flow restriction may not be compensated. The factors mentioned above can affect vision loss in a complex fashion. The Fig. 4 was created by Jong Suk Lee who is one of the co-authors