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Table 1 Preoperative data from groups 1 and 2 during the first week after neovascular glaucoma diagnosis

From: Visual prognosis and surgical timing of Ahmed glaucoma valve implantation for neovascular glaucoma secondary to diabetic vitrectomy

 

Total (n = 35)

Group 1 (n = 16)

Group 2 (n = 19)

P-value

Baseline characteristics

    

Age (years)

58.4 ± 10.3

58.4 ± 10.3

51.9 ± 10.2

0.246†

Sex (M/F)

22/13

8/8

14/5

0.179‡

Laterality (R/L)

18/17

7/9

11/8

0.505‡

VA (LogMAR)

    

BCVA before NVG diagnosis

0.85 ± 0.62

0.88 ± 0.50

0.82 ± 0.71

0.483†

VA at the time of NVG diagnosis

1.67 ± 0.79

2.13 ± 0.50

1.28 ± 0.71

0.008†

IOP at the time of NVG diagnosis (mmHg)

40.2 ± 8.3

41.3 ± 8.3

39.3 ± 8.2

0.905†

Lens status (Phakic/Pseudophakic)

5/30

3/13

2/17

0.642‡

Non-surgical treatment and therapeutic response during the first week after NVG diagnosis

    

No. of IOP-lowering medications

2.51 ± 0.69

2.13 ± 0.78

2.84 ± 0.36

0.005†

AC paracentesis (%)

14 (40.0)

6 (37.5)

8 (42.1)

1.000‡

Anti-VEGF injections (%)

27 (77.1)

12 (75.0)

15 (78.9)

1.000‡

Add PRP

5 (14.3)

1 (6.3)

4 (21.1)

0.347‡

Last IOP within the first week (mmHg)

30.2 ± 11.3 *

38.7 ± 8.3 **

22.3 ± 7.2 ***

0.000†

Delta IOP (mmHg)

(IOP at the day of NVG diagnosis - IOP at the last day within the first week)

11.3 ± 10.8 *

3.0 ± 7.7 **

19.0 ± 6.8 ***

0.000†

Delta IOP > 10 mmHg (%)

16 (45.7)

3 (23.1)

13 (68.4)

0.000‡

  1. * Except for eight cases who received immediate AGVI or did not visit within one week from NVG diagnosis
  2. ** Except for three cases who received immediate AGVI
  3. *** Except for five cases who did not visit within one week from NVG diagnosis
  4. † Calculated using an independent t-test and Mann Whitney test
  5. ‡ Calculated using a Chi-Square test and Fisher’s Exact test
  6. Abbreviations: NVG, neovascular glaucoma; M, male; F, female; R, right; L, left; No., number; IOP, intraocular pressure; AC, anterior chamber; AGVI, Ahmed glaucoma valve implantation; Add PRP, additional pan-retinal photocoagulation
  7. Group 1, Group of NVG patients who maintained an IOP of 30 mmHg or more before AGVI despite initial non-surgical treatment including maximum tolerable medical treatment; Group 2, Group of NVG patients who responded well to initial non-surgical treatment but eventually required AGVI.