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Table 4 Stratification of IOP values of PEG, PEX and control groups with respect to CLU rs2279590 C/T, rs11136000 C/T, rs1532278 C/T, and rs3087554 T/C genotypes in a recessive model

From: Influence of clusterin genetic variants on IOP elevation in pseudoexfoliation syndrome and pseudoexfoliative glaucoma in Turkish population

 

Genotype

PEG (n = 239)

PEX (n = 240)

Control (n = 240)

P

rs2279590 C/T

CC

21.9 ± 5.0 21.0 (18.0 – 24.0)

20.6 ± 5.6 19.5 (18.0 – 23.0)

19.2 ± 4.8 19.0 (16.0 – 22.0)

.002 a, < .001b, .153 c, .046 d

CT

21.2 ± 4.9 21.0 (18.0 – 24.0)

19.0 ± 4.5 18.0 (18.0 – 22.0)

19.6 ± 5.9 18.0 (16.0 – 23.0)

.005 a, .011 b, .658 c, .002 d

TT

22.4 ± 6.7 21.5 (18.0 – 25.0)

22.3 ± 6.6 21.5 (18.0 – 26.0)

21.0 ± 6.2 19.0 (16.5 – 25.0)

.363a

P*

.603

.009

.181

 

rs11136000 C/T

CC

21.8 ± 5.0 21.0 (18.0 – 24.0)

20.5 ± 5.6 19.5 (17.0 – 23.0)

19.3 ± 4.8 19.0 (16.0 – 22.0)

.005 a, .001b, .189 c, .056 d

CT

21.4 ± 4.9 21.0 (18.0 – 24.0)

18.9 ± 4.4 18.0 (16.0 – 22.0)

19.6 ± 5.9 18.0 (16.0 – 23.0)

.002 a, .005 b,.629 c, .001 d

TT

22.3 ± 6.9 20.5 (18.0 – 25.0)

22.4 ± 6.6 22.0 (18.0 – 26.0)

20.9 ± 6.2 19.0 (16.0 – 25.0)

.322 a

P*

.819

.007

.241

 

rs1532278 C/T

CC

21.8 ± 5.0 21.0 (18.0 – 24.0)

20.5 ± 5.6 20.0 (17.5 – 23.0)

19.3 ± 4.8 19.0 (16.0 – 22.0)

.005 a, .001 b, .177 c, .059 d

CT

21.4 ± 4.9 21.0 (18.0 – 24.0)

18.9 ± 4.4 18.0 (16.0 – 22.0)

19.6 ± 5.9 18.0 (16.0 – 23.0)

.002 a, .005 b, .651 c, .001 d

TT

22.3 ± 6.9 20.5 (18.0 – 25.0)

22.4 ± 6.7 21.5 (18.0 – 26.0)

20.9 ± 6.2 19.0 (16.0 – 25.0)

.361 a

P*

.819

.010

.248

 

rs3087554 T/C

TT

21.7 ± 5.8 21.0 (18.0 – 24.0)

20.4 ± 5.6 19.0 (17.0 – 23.0)

19.9 ± 5.8 19.0 (16.0 – 23.5)

.007 a, .002 b, .272 c, .044 d

TC

21.8 ± 4.4 22.0 (19.0 – 23.0)

18.9 ± 5.0 18.0 (16.0 – 21.0)

19.5 ± 5.1 18.0 (16.0 – 22.0)

 < .001 a, .005 b, .428 c, .000 d

CC

21.6 ± 3.8 20.0 (19.0 – 26.0)

21.0 ± 5.0 20.0 (20.0 – 22.0)

18.2 ± 3.0 18.0 (16.0 – 21.0)

.305 e

P*

.934

.306

.557

 
  1. Data were expressed as mean ± SD in the first row, and median (Q1-Q3 quartiles) in the second row. a Comparison of three groups (PEG vs. PEX vs. Control) by Kruskal–Wallis test. b PEG vs. Control; c PEX vs. Control; d PEG vs. PEX by Conover’s formula. e Comparison of three groups (PEG vs. PEX vs. Control) by One-Way ANOVA. * P value is for recessive model; TT vs. CT + CC for rs2279590 C/T, rs11136000 C/T, rs1532278 C/T; CC vs. TC + TT for rs3087554 T/C by Mann–Whitney U test. Bonferroni corrected significance cut-off value was .0125