Fig. 4

Pathological findings in a typical case (patient 1). A and B: Schematic diagrams of bleb sections and pathological examination of each section. C: Section C1 is located in the corneal conjunctival margin. The Bowman membrane can be seen (black arrow). D Section B2 is located within the corneal limbus. No epithelial tissue is present inside the filtering bleb, except for the conjunctival epithelium on the surface (arrow). The Bowman membrane has disappeared, indicating that the filtering bleb has invaded into the corneal stroma. E Section B3. At the lower end of the filtering bleb (at the junction with the normal corneal tissue), the corneal epithelium and conjunctival epithelium are continuous rather than in a face-to-face arrangement, indicating that the filtering bleb has invaded the cornea rather than hanging over the cornea