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Table 1 The characteristics of the included studies in this meta-analysis

From: The efficacy and safety of micropulse transscleral laser treatment in glaucoma: a systematic review and meta-analysis

Author/year

Abdelrahman 2018 [21]

Abdullatif 2021 [28]

Aquino 2015 [44]

Bernardi 2022 [45]

Fili 2022 [46]

Zemba 2022 [18]

Research type

Prospective study

RCT

RCT

Retrospective study

Prospective study

Retrospective study

Age (mean ± SD)

(mTLT / CW-TSCPC)

67.8 ± 48 / 61.3 ± 38.3 months

48.6 ± 6.6 /

53 ± 10.6 years

63.50 (54.75,74) /

66 (55, 72.75) years

68.9 ± 13.3 /

73.1 ± 15.5 years

77.77 ± 10.97 years

55.6 (range, 44‑79) /

58.1 (range, 32‑87) years

Type of glaucoma

PCG, Aphakia/pseudophakia Aniridia glaucoma, Peter’s anomaly, Microspherophaki, Sturge Weber glaucoma

open-angle glaucoma

POAG, PACG, NVG, Silicone oil, Aphaki, Traumatic glaucoma

POAG, ACG, PEXG, PDG, Aphakic glaucoma, OHT, Others

POAG, PEXG

NVG

Characteristics of mTLT (power, duration)

2000 mW, a duty cycle of 31.3%, 100 to 120 s

2000 mW, a duty cycle of 31.3%, 200 s

2000 mW, a duty cycle of 31.3%, 100 s

2000 mW, a duty cycle of 31.3%, 160 s

2500 mW, a duty cycle of 31.3%, >160 s

2000 mW, a duty cycle of 31.3%, 180 s

Characteristics of CW-TSCPC (power, duration)

1.5 W, 45 s

1.5–2 W, 40–56 s

1.5–2 W, 40–56 s

2 W, 37.5 s

2–2.3 W, 36 s

1.25 W, 80–84 s

No. of eyes (mTLT / CW-TSCPC)

17 / 28

10 / 10

24 / 24

47 / 150

15 / 15

24 / 22

Duration of follow-up (months)

6

6

18

12

12

12

Baseline IOP (mmHg, mean ± SD)(mTLT / CW-TSCPC)

28.3 ± 8.2 /

27.5 ± 6.1

18.7 ± 2.9 /

19.8 ± 5.0

36.5 (29.5, 56.5) /

35.0 (29.5, 46.5)

22.0 ± 7.2 /

28.3 ± 12.3

17.75 ± 6.92 /

19.13 ± 7.27

34.7 ± 10.3 /

36.0 ± 13.2

IOP reduction at the last visit (%) (mTLT / CW-TSCPC)

63 ± 28 /

67 ± 25

23.9 ± 6.1 /

31.5 ± 25.3

-

31.1 / 43.7

-

23.0 / 33.6

Success rates at the last visit (%) (mTLT / CW-TSCPC)

71 / 46

60 / 50

52 / 30

87.5 / 88.6

60 / 20

33.3 / 54.5

  1. RCT: randomized controlled trial; mTLT: micropulse transscleral laser treatment; CW-TSCPC: continuous wave transscleral cyclophotocoagulation; PCG: primary congenital glaucoma; POAG: primary open angle glaucoma; PACG: primary angle-closure glaucoma; NVG: neovascular glaucoma; ACG: angle-closure glaucoma; PEXG: pseudoexfoliative glaucoma; PDG: Pigment dispersion glaucoma; OHT: ocular hypertension