Table 1 Summary of the sample (n = 280) extracted from PEDIG’s ATS13 and ATS5. Comparison between three groups (anisometropic, strabismic and mixed amblyopia) in baseline, final and change for: VAAE (LogMAR), interocular difference in VA (IOD-VA) (LogMAR), Tropia at Distance (Δ = prismatic diopter), Tropia at Near (Δ), stereoacuity level [1 (40”) to 7 (> 800”)] and elapsed time (days) for each group and for the whole sample, from baseline to the end of the OTA phase. Initial stereoacuity data for the anisometropic group were unavailable. The non-parametric Wilcoxon test has been used to compare baseline and end-of-OTA measures

VA AE LogMar

Mean ± SD

Median

0.53 ± 0.22

0.50

0.29 ± 0.23

0.30

-0.24 ± 0.17

0.20

Z= -8,097

P < 0.001*

0.60 ± 0.23

0.60

0.33 ± 0.23

0.30

-0.27 ± 0.21

0.29

Z= -7,395

P < 0.001*

0.67 ± 0.23

0.60

0.44 ± 0.30

0.40

-0.23 ± 0.19

0.20

Z= -7,639

P < 0.001*

IOD LogMAR

Mean ± SD

Median

0.50 ± 0.23

0.49

0.32 ± 0.22

0.30

-0.18 ± 0.18

-0.19

Z= -7,285

P < 0.001*

0.46 ± 0.20

0.40

0.28 ± 0.22

0.20

-0.18 ± 0.18

-0.19

Z= -6,806

P < 0.001*

0.56 ± 0.25

0.50

0.41 ± 0.28

0.30

-0.15 ± 0.19

-0.19

Z= -6,284

P < 0.001*

Tropia Distance (∆)

Mean ± SD

Median

Percentile (P25, P75)

-

-

-

-

10 ± 10

8

(4, 15)

4 ± 6

2

(0, 6)

6 ± 10

2

(0, 10)

Z= -5,227

P < 0.001*

7 ± 8

4

(2, 12)

4 ± 6

2

(0, 5)

3 ± 5

2

(0, 4)

Z= -3,618

P < 0.001*

Tropia Near (∆)

Mean ± SD

Median

Percentile (P25, P75)

-

-

-

-

13 ± 10

10

(5, 20)

7 ± 7

4

(2, 12)

6 ± 1

4

(2, 10)

Z= -5,766

P < 0.001*

9 ± 8

7

(2, 14)

7 ± 7

4

(2, 10)

2 ± 5

2

(0, 5)

Z= -4,459

P < 0.001*

Stereo (levels 1 to 7)

Mean ± SD

-

4.81 ± 2.02

-

-

6.49 ± 1.01

5.81 ± 1.79

-0.96 ± 0.23

Z= -3.810

P < 0.001*

6.51 ± 0.98

5.82 ± 1.69

-0.66 ± 0.15

Z= -3.899

P < 0.001*

Optical treatment period (days)

151 ± 73

158 ± 63

171 ± 70

Global average Optical treatment for 3 groups (days)

160.3 ± 69