Inflammatory bowel disease and the associated risk of dry eye and ocular surface injury: a nationwide matched cohort study

Table 2 Risk of dry eye and ocular surface damage for subjects with and without inflammatory bowel disease

	IBD n = 54,293		Non-IBD n = 54,293		Outcome risk
Study outcome	Incident case	Incidence per 1000 person-years	Incident case	Incidence per 1000 person-years	IRR	aHR (95% CI)	p
Dry eye disease	3421	8.18	2295	5.42	1.51	1.43 (1.35 – 1.51)	< .0001
Sjögren’s syndrome-related	634	1.47	354	0.82	1.79	1.67 (1.46 – 1.90)	< .0001
Non-Sjögren’s syndrome-related	2787	6.67	1941	4.58	1.46	1.38 (1.30 – 1.46)	< .0001
Corneal surface damage	1003	2.34	866	2.02	1.16	1.13 (1.03 – 1.24)	0.0094
Corneal ulcer	603	1.41	557	1.30	1.08	1.06 (0.95 – 1.20)	0.2988
Recurrent corneal erosion	212	0.49	137	0.32	1.53	1.52 (1.22 – 1.88)	0.0002
Corneal opacity	188	0.44	173	0.40	1.10	1.04 (0.84 – 1.29)	0.7048

Abbreviation: aHR adjusted hazard ratio, CI confidence interval, IBD inflammatory bowel disease, IRR incidence rate ratio

ISSN: 1471-2415