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Table 3 Corvis ST parameters with AUC > 0.6 in distinguishing subclinical keratoconus corneas from normal ones

From: Corneal biomechanics in normal and subclinical keratoconus eyes

Variable

AUC (95% CI)

Optimal threshold

Sensitivity

Specificity

Youden index

Significance level P (Area = 0.5)

ARTh

0.813 (0.740, 0.874)

≤ 488.1

78.08%

79.71%

0.5779

< 0.0001

CBI

0.804 (0.729, 0.866)

> 0.47

78.08%

71.01%

0.4910

< 0.0001

TBI

0.858 (0.790, 0.911)

> 0.33

78.08%

76.81%

0.5489

< 0.0001

DA ratio

0.632 (0.547, 0.711)

> 4.1

73.97%

47.83%

0.2180

0.0048

SPA1

0.602 (0.516, 0.683)

≤ 106.8

84.93%

33.33%

0.1826

0.0321

  1. AUC Area under the curve, CI Confidence interval, ARTh Ambrósio relational thickness to the horizontal profile, CBI Corvis biomechanical index, TBI Tomographic and biomechanical index, DA Deformation amplitude, SPA1 Stiffness parameter at the first applanation