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Table 3 Subgroup analysis of immediate postoperative pain and cooperation scores between the study groups

From: Topical and subconjunctival anesthesia versus topical anesthesia alone in patients with senile cataracts undergoing phacoemulsification: a double-blind randomized controlled trial

 

Control group, n (%)

Lidocaine group, n (%)

p

 

Subgroup: Nuclear cataract 1–3

 
 

n= 70

n= 61

 

Immediate postoperative pain

< 0.001

 - No pain

10 (14.3)

28 (45.9)

 

 - Mild

47 (67.1)

31 (50.8)

 

 - Moderate

11 (15.7)

2 (3.3)

 

 - Severe

2 (2.9)

0 (0)

 

Cooperation score* (Median [IQR])

0 (0, 1)

0 (0, 1)

0.402

 - Score difference (95% confidence interval)

−0.10 (− 0.34, 0.14)

 

Subgroup: Mature cataracts

 
 

n= 18

n= 27

 

Immediate postoperative pain

0.208

 - No pain

4 (22.2)

10 (37.0)

 

 - Mild

13 (72.2)

17 (63.0)

 

 - Moderate

1 (5.6)

0 (0)

 

 - Severe

0 (0)

0 (0)

 

Cooperation score* (Median [IQR])

1 (0, 2)

0 (0, 1)

0.016

 - Score difference (95% confidence interval)

−0.82 (− 1.47, − 0.16)

 

Subgroup: Second-eye operation

 
 

n= 26

n= 26

 

Immediate postoperative pain

0.022

 - No pain

4 (15.4)

10 (38.5)

 

 - Mild

17 (65.4)

16 (61.5)

 

 - Moderate

4 (15.4)

0 (0)

 

 - Severe

1 (3.8)

0 (0)

 

Cooperation score* (Median [IQR])

0 (0, 1)

0 (0, 1)

0.495

 - Score difference (95% confidence interval)

−0.15 (− 0.60, 0.30)

 

Subgroup: Prolonged operation

 
 

n= 11

n= 14

 

Operative time (minutes) (Median [IQR])

25 (24, 28)

25 (23, 33)

Immediate postoperative pain

0.239

 - No pain

1 (9.1)

4 (28.6)

 - Mild

7 (63.6)

9 (64.3)

 - Moderate

3 (27.3)

1 (7.1)

 - Severe

0 (0)

0 (0)

Cooperation score* (Median [IQR])

2 (1, 2)

0 (0, 1)

0.006

 - Score difference (95% confidence interval)

−1.14 (− 1.92, -0.35)

  1. * The patient cooperation score ranged 0–5. A score of 5 indicated the worst cooperation, whereas a score of 0 denoted the best cooperation
  2. The reported results were derived from ordinal logistic regression analysis for immediate postoperative pain and linear regression with robust standard errors for the cooperation score
  3. Prolonged operation = patients who had operative time exceeding the 75th percentile of the entire population’s operative time
  4. IQR, interquartile range