Fig. 2

Patient 9’s multimodal imaging showed characteristics of MEWDS. Wide-angle fundus photography of the left eye revealed multiple yellow lesions distributed on the retina (arrows) (A, B). Flaky hyperfluorescent on the temporal side of the optic disc was observed in the infrared fundus image. (C)Early-phase FFA showed scattered punctate hyperfluorescence (D), while mid-to-late phase showed staining around the optic disc with blurred margins arranged in a wreath-like pattern, consistent with the location of spontaneous fluorescence (E, F). FAF exhibited various-sized patchy areas of hyperfluorescence near the optic disc and posterior pole as well as uneven diffuse hyperfluorescence (G). ICGA showed normal choroidal background fluorescence in early-phase with no abnormality observed in the large and medium vessels. In the mid-to-late phase, multiple scattered weakly fluorescent lesions were observed in the choroid around the optic disc, macular area, and mid-periphery, varying in size, and some lesions fused into small patches. (H–J) MEWDS: multiple evanescent white dot syndrome; FFA: fluorescein angiography; ICGA: indocyanine green angiography