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Table 4 Tear inflammatory cytokines and neuropeptide concentrations of participants before and after treatment

From: Efficacy of topical 0.05% cyclosporine A and 0.1% sodium hyaluronate in post-refractive surgery chronic dry eye patients with ocular pain

Concentrations (pg/ml)

Baseline

1 m

3 m

P-value

IFN-γ - mean (SD)

41.91 ± 58.26

47.18 ± 26.85

43.87 ± 49.87

0.82

IL-10 - mean (SD)

56.19 ± 61.57

60.65 ± 103.74

46.47 ± 32.82

0.18

IL-17 A - mean (SD)

50.37 ± 86.65

52.62 ± 86.04

42.38 ± 26.14

0.59

IL-1β- mean (SD)

6.64 ± 2.62

5.77 ± 4.64

4.10 ± 3.23

0.01

IL-23 - mean (SD)

1653.00 ± 2452.30

1184.77 ± 1167.66

1027.63 ± 584.39

0.28

 

IL-6 - mean (SD)

23.13 ± 18.08

18.14 ± 8.49

15.26 ± 7.08

0.03

TNF-α- mean (SD)

29.26 ± 20.38

28.01 ± 17.42

20.02 ± 8.10

0.02

α-MSH - mean (SD)

223039.65 ± 151360.67

257683.48 ± 148820.68

292800.05 ± 139057.84

0.11

Oxytocin - mean (SD)

149426.33 ± 96328.34

155149.79 ± 74552.44

175864.65 ± 63998.12

0.37

SP - mean (SD)

37922.01 ± 35813.01

40321.37 ± 19040.77

46294.62 ± 17023.66

0.24

  1. INF-γ, Interferon-γ; IL, interleukin; TNF-α, tumor necrosis factor-α; α-MSH, alpha-melanocyte stimulating hormone; SP, substance P; SD, standard deviation. P<0.05 with mixed linear model